低氧条件下甘肃鼢鼠鼻黏膜内含SP及CGRP的免疫反应纤维长度变化

Substance P and Calcitonin Gene-related Peptide Immunoreactive Nervefibers in Nasal Mucosa of Chronically Hypoxic Myospalax cansus

运用免疫组织化学方法对比了常氧条件下与低氧条件下甘肃鼢鼠鼻黏膜内含P物质(SP)及降钙素基因相关肽(CGRP)的神经纤维平均长度的变化情况。结果表明,甘肃鼢鼠在低氧条件下,鼻腔嗅黏膜内含SP及CGRP的免疫反应纤维的平均长度与常氧条件下的比率分别为0.97和1.09,呼吸黏膜的比率分别为1.20和1.22,明显小于SD大鼠的相应比率,但差异均未达极显著水平(0.01<P<0.05),从而推断,甘肃鼢鼠对低氧环境的不敏感性是其对极端生存环境的一种适应性特征。

Using immunohistochemical technique,the length of SP-immunoreactive and CGRP-immunoreactive nerve fibers in the nasal mucosa was compared between normoxic and chronically hypoxic Myospalax cansus. Compared with normoxic mucosa, the ratios of average length of SP- and CGRP-immunoreactive nerve fibers in olfactory mucosa in hypoxic Myospalax cansus were 0.97 and 1.09,the ratios of average length of SP- and CGRP-immunoreactive nerve fibers in respiratory mucosa in hypoxic Myospalax cansus were 1.20 and 1.22,which were obviously smaller than those of SD rat,but they didn＇t reach the very significant levels（P〈0.05）. It suggests that hypoxic environment has no greater impact on upper respiratory tract of Myospalax cansus. Thus, the upper respiratory tract in Myospalax cansus is thought to be not highly sensitive to hypoxic entironment, which adapts to the extremely living environment.