摘要
目的探讨腹膜透析患者血清纤维结合蛋白含量变化及其临床意义。方法应用透射免疫分析法测定70例尿毒症患者进行腹膜透析前后的血清纤维结合蛋白(Fn)含量,同时检测血清肌酐(Crea)、血清尿素氮(BUN)含量,并进行相关性统计分析。结果与正常对照组(223.7±11.7)mg/L比较,腹透前组(168.07±16.06)mg/L、腹透后组(191.77±17.01)mg/L Fn含量降低,差异有统计学意义(P<0.05);腹透后组与腹透前组比较,Fn水平升高,差异有统计学意义(P<0.05);透析前、后Fn升高水平与Crea、BUN降低水平的变化趋势均不完全一致。结论对进行腹膜透析治疗的尿毒症期患者进行Fn水平检测,有助于监测透析患者腹膜纤维化的情况及判断患者腹膜透析的效果,可作为评估腹膜透析效果辅助指标之一。
Objective To study the level changes of serum Fibronectin （Fn） and the clinical application of detection of Fn in patients with peritoneal dialysis. Methods Serum Fn, Crea and BUN of 70 patients with peritoneal dialysis were determined. The outcomes were analyzed by T-test assay. Results The levels of serum Fn in patients with peritoneal dialysis were （ 168. 07± 16. 06） mg/L and （ 191.77 ± 17.01 ） mg/L, markedly lower than the level of （ 223.7 ±11.7 ） mg/L in normal control group （ P 〈 0. 05 ） . Compared with patients group before peritoneal dialysis, the level of serum Fn in patients group after peritoneal dialysis increased （ P 〈 0. 05 ） . There was correlation among serum Fn, Crea and BUN in patients group before peritoneal dialysis and patients group after peritoneal dialysis. Conclusion Determination of Fn peritoneal dialysis patients can help monitor the situation fibrosis; Fn determination can help determine the effect of peritoneal dialysis patients.
出处
《广州医药》
2013年第2期1-4,共4页
Guangzhou Medical Journal
