C-反应蛋白、同型半胱氨酸、血尿酸及胆红素在冠心病患者中的临床意义

The clinical significance of C-reactive protein,homocysteine,uric acid and bilirubin in patients with coronary heart disease

目的:研究冠心病患者中C-反应蛋白、同型半胱氨酸、血尿酸及胆红素含量的变化,并了解其临床意义及对疾病的预后。方法:收集200例冠状动脉综合征患者及50例正常对照着的血清标本,检测C-反应蛋白、同型半胱氨酸、血尿酸及胆红素水平,对照比较分析。结果:冠心病组总胆红素、间接胆红素均低于非冠心病组,分别为(14.94±4.12)umol/L vs(19.78±9.49)umol/L,P=0.003;(10.36±4.73)umol/L vs(14.69±6.57)umol/L,P=0.017,而C-反应蛋白、同型半胱氨酸、血尿酸水平均高于非冠心病组,分别为(9.79±2.46)umol/L vs(2.48±1.32)umol/L,P=0.012;(19.58±5.32)umol/L vs(5.26±2.01)umol/L,P=0.002;(364.3±110.2)umol/L vs(225.6±61.3)umol/L,P=0.009。心肌梗死组C-反应蛋白、同型半胱氨酸及血尿酸均高于非心肌梗死组(P<0.05)。高水平C-反应蛋白与高同型半胱氨酸、高血尿酸及低胆红素有明显的相关性。结论:C-反应蛋白、血尿酸、同型半胱氨酸及总胆红素水平可能是反映冠心病严重程度的指标,在冠心病的发生发展中起重要作用。

Objective To study C-reactive protein,homocysteine？？,uric acid and bilirubin content in patients with coronary heart disease,and understand their clinical significance and prognosis of the disease.Methods Collected 200 cases of coronary syndrome and 50 patients with normal serum samples according to the detection of C-reactive protein,homocysteine,uric acid and bilirubin levels,Comparison analysis.Results The CHD group total bilirubin,indirect bilirubin were lower than the non-CAD group was（14.94±4.12） umol/L vs（19.78±9.49）umol/L,P=0.003;（10.36±4.73） umol/L vs（14.69±6.57）umol/L,P=0.017,and C-reactive protein,homocysteine,hematuria acidic water on average than non-CAD group,was（9.79±2.46） umol/L vs（2.48±1.32）umol/L,P=0.012;（19.58±5.32） umol/L vs（5.26±2.01）umol/L,P=0.002;（364.3±110.2） umol/L vs（225.6±61.3）umol/L,P=0.009.Myocardial infarction,C-reactive protein,homocysteine and uric acid were higher than the non-MI group,P0.05,High levels of C-reactive protein and homocysteine,high blood uric acid and low bilirubin significant correlation.Conclusions We conclude that C-reactive protein,uric acid,homocysteine,and total bilirubin levels may reflect the indicator of the severity of coronary heart disease,plays an important role in the development of coronary heart disease.