扩张型心肌病致病机制的研究进展

Advances in pathogenic mechanism of dilated cardiomyopathy

扩张型心肌病（dilated cardiomyopathy，DCM）是儿童心肌病中最常见的类型。目前认为其可能与基因突变、病毒感染、自身免疫损伤、营养元素缺乏、药物诱发、内分泌代谢异常等相关。维生素D通过平衡体内钙离子含量，负调控肾素一血管紧张素一醛固酮系统及降低炎症介质的生成，降低DCM的发生率。该文阐述DCM的发病机制及治疗的最新研究进展，并着重讨论维生素D缺乏及基因突变导致DCM发生的作用机制及预后。

Dilated cardiomyopathy （DCM） is the most common type of cardiomyopathy in children. It is associated with gene mutation, viral infection, autoimmunity, nutritional deficiency, drug induced, endocrine and metabolic abnormalities, et al. Through the balance of the calcium content, the negative control of renin-angiotensin-aldosterone system and the reduction of the formation of inflammatory mediators, vitamin D can reduce the occurrence of DCM. This paper elaborates the latest research advances of the DCM pathogenesis and treatment, especially focusing on the mechanism and prognosis of vitamin D deficiency and gene mutation.