杜氏肌营养不良与骨骼肌纤维化

Duchenne muscular dystrophy and skeletal muscle fibrosis

骨骼肌纤维化是杜氏肌营养不良杜氏肌营养不良的主要病理变化之一，可影响肌纤维的再生、收缩功能，加重病情，在骨骼肌纤维化的发生发展过程中，炎症细胞、成纤维细胞、成肌纤维细胞及其分泌的细胞因子起重要作用。该文对杜氏肌营养不良的骨骼肌纤维化研究进展进行综述。

Skeletal muscle fibrosis is one of the main pathological changes of Duchenne muscular dystrophy （ DMD）, which can affect the regeneration of muscle fiber and promote development of the disease. Its occurrence and development correlate closely with inflammatory cells, fibroblasts, myofibroblasts and cytokines. This article reviews the progress of skeletal muscle fibrosis of DMD