儿童神经母细胞瘤相关基因的单核苷酸多态性研究进展

Progress in gene single nucleotide polymorphism associated with neuroblastoma

神经母细胞瘤病因复杂，涉及遗传、环境、代谢等多种因素，其中遗传因素是重要原因之一。近年来，随着分子生物学的发展，对神经母细胞瘤基因水平的研究越发深入，除N-myc基因扩增、染色体异常等较为明确的与神经母细胞瘤密切相关的因素外，部分基因的单核苷酸多态性也被证实与神经母细胞瘤的发病显著相关。该文对近年来有关神经母细胞瘤的单核苷酸多态性研究进展作一综述。

The etiology of neuroblastoma is related with hereditism, enviroment and matabolic factors. By now, it has been confirmed that N-myc amplification, chromosome abnormality, and some certain gene mutations are related with neuroblastoma. However, since the development of molecular biology, some single nucleotide polymorphismes in certain genes have been established to play an important role in neuroblastoma. It is necessary to summarize the latest studies about single nucleotide polymorphism in neuroblastoma.