促红细胞生成素联合不同剂量维生素E在防治早产儿贫血中的临床研究

Therapeutic effects of erythropoietin and different doses of vitamin E on the prevention of anemia in pre- mature children

目的探讨维生素E（VitE）在防治早产儿贫血中的临床疗效。方法选择我院新生儿病房2010年12月至2011年12月收治的早产儿90例，按入住先后顺序随机分为对照组（A组）、VitE大剂量组（B组）、VitE小剂量组（C组）。A组30例，入院后第7天起给予促红细胞生成素（EPO），每周750IU／kg分3次皮下注射，共4周；同时加服铁剂每日6mg／kg。另2组在上述对照治疗的基础上，加服不同剂量VitE，共4周。B组30例，VitE每日15mg／kg；c组30例，VitE每Et2．5mg／kg。观察治疗过程中各组血细胞压积（Hct）、血红蛋白（Hb）、红细胞（RBC）、网织红细胞（Ret）及其治疗前后血清VitE浓度的变化。结果治疗后B、C组患者Hct、Hb、RBC、Ret均有所改善，各项指标改善程度与A组比较，差异有统计学意义（P〈0．05），B与C组各项指标改善程度未见明显差异（P〉0．05）。B、C组治疗后血清VitE浓度可见明显升高，且差异有统计学意义（P〈0．05），A组患者上升不明显。结论在EPO防治早产儿贫血的同时应加腽小剂量VitE．

Objective To research the therapeutic effect of vitamin E in prevention and treatment of anemia in premature children. Methods We investigated 90 cases of premature children admitted to the neonatal ward of our hospital from December 2010 to December 2011. According to hospital successively order these premature were randomly divided into control group （Group A ）, high-dose group （Group B ）, low-dose group （ Group A）. Group A including 30 cases, subcutaneous injection of erythropoietin （EPO） from the 7th days after admission ,750IU/kg weekly for 3 times ,for 4 weeks. At the same time,plus iron 6mg/（kg·d）. On the basis of the above-mentioned control treatment, oral administration of different doses of vitamin E was in the treatment group ,for 4 weeks. Group B including 30 cases was given vitamin E 15mg/（kg·d）. Group C including 30 cases was given vitamin E 2. 5 rag/（ kg· d）. The changes of each group during the treatment in hematocrit （Hct）, hemoglobin （ Hb ）, red blood cell （ RBC）, reticulocyte （Ret） and the changes of serum concentrations of vitamin E before and after treatment were observed. Results Hct, Hb, RBC, Ret in group B, group C patients were both improved. The improvement of the indicators was better than that of group A （ P 〈 0. 05 ）. There was no significant difference between the improvement of each index of Group B and Group C（ P 〉 0. 05 ）. Serum concentrations of vitamin E after treatment in group B and group C patients were significantly higher and the difference was statistically significant（ P 〈0. 05）. Serum concentration of vitamin E in group A didn＇t increase obviously. Conclusion Additional small doses of VitE should be given during EPO prevention of anemia in premature children.