摘要
破骨细胞形成抑制因子 (OPG/OCIF)是最近发现的一种参与调节骨密度的糖蛋白 ,是一个肿瘤坏死因子(TNF)受体超家族的新成员 ,其氨基酸序列中具有TNF受体结构类似区 .成熟的OPG/OCIF具有 7个结构域 ,可分为三个功能区 ,即 :TNF受体结构区、致死结构区和肝素结合区 .OPG/OCIF基因定位在 8q2 3～ 2 4上 ,由5个外显子和 4个内含子组成 ,其表达受到与骨的形成和破坏有关因子的调控 :如TGF β1、 1,2 5 (OH) 2 VD3、TNF α等等 .OPG/OCIF抑制骨的破坏和吸收机制主要是抑制破骨细胞的存活 。
Osteoclastogenesis inhibitory factor or osteoprotegerin(OPG/OCIF) is a novel secreted glycoprotein involved in the regulation of bone density. It is a novel member of the TNF receptor superfamily. Mature OPG/OCIF contains 7 domains and can be divided into 3 regions(TNF receptor cysteine rich region; death domain region and heperin binding region). The OPG/OCIF gene is a single copy gene consisting of five exons and four introns. It is located in 8q23～24. The factors involved in the regulation of bone formation and resoption(eg. TGF β1,1,25(OH) 2VD 3 and TNF α)regulate the expression of OPG/OCIF gene. The mechanisms by which OPG/OCIF inhibits bone resoption can be concluded that: 1) OPG/OCIF inhibits survival of osteoclasts and induces apoptosis of osteoclasts; 2) OPG/OCIF inhibits formation of osteoclasts.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2000年第5期469-472,共4页
Progress In Biochemistry and Biophysics
关键词
破骨细胞形成抑制因子
细胞凋亡
TNF
糖蛋白
osteoclastogenesis inhibitory factor, TNF receptor surperfamily, apoptosis
