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冠状动脉旁路移植术的计算流体力学研究及其临床应用 被引量：3

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摘要 冠状动脉旁路移植术（coronary artery bypass graft，CABG）广泛开展了半个世纪，疗效也被广泛认可[1]。但是，近40％的桥血管会在8年内发生闭塞[2]，最终导致手术失败。整个再狭窄的病理过程已经明确㈨：术后1年内，吻合口处的内膜层m现平滑肌细胞、炎性细胞以及细胞外基质的堆积，形成内膜增生，且多位于脚跟、脚尖以及血管床，见图1；随后5年内，内膜增生会发展成粥样斑块，最后则出现吻合口的再狭窄。
作者 戴晨阳 连锋 薛松
机构地区 上海交通大学医学院附属仁济医院心血管外科
出处 《中华生物医学工程杂志》 CAS 2012年第6期507-510,共4页 Chinese Journal of Biomedical Engineering
基金 上海市卫生局科研课题（20114243）
关键词 冠状动脉旁路移植术 临床应用 力学研究 流体 ARTERY 内膜增生 平滑肌细胞 细胞外基质
分类号 R654.2 [医药卫生—外科学]
  • 相关文献

参考文献31

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  • 2Hata M, Yushitake I, Wakui S, et al.Long-term patency rate for radial artery vs. saphenous vein grits using same-patient materials. Circ J, 2011,75: 1373-1377.
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  • 4John LC. Biomechanics of coronary artery and bypass graft disease: potential new approaches. Ann Thorac Surg, 2009, 87: 331-338.
  • 5Stone PH, Coskun AU, Kinlay S, et al. Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study. Eur Heart J, 2007, 28: 705-710.
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二级参考文献81

  • 1刘有军,乔爱科,主海文,高松.颈动脉分支的血流动力学数值模拟[J].计算力学学报,2004,21(4):475-480. 被引量：17
  • 2邓小燕,刘柳军,王贵学.脉动流条件下动脉狭窄血管内脂质浓度极化现象的计算机数值模拟[J].计算力学学报,2005,22(1):25-31. 被引量：12
  • 3邱霖,陈榕生,岑人经,袁支润.岔动脉血管脉动血流的动力学分析[J].生物医学工程研究,2004,23(2):67-70. 被引量：1
  • 4蒋文涛,樊瑜波,邹远文,陈君楷.窦部对称狭窄对颈动脉内流场影响的数值研究[J].力学学报,2006,38(2):270-275. 被引量：4
  • 5Ghassan S. Kassab, Jose A. Navia. Biomechanical considerations in the design of gralt: the homeostasis hypothesis [ J ]. Annual Review of Biomedical Engineering, 2006.8: 499-535.
  • 6Rainald L, Juan C, Orlando S, et al. ,Applications of patient-specific CFD in medicine and life sciences [ J ]. International journal for numerical methods in fluids, 2003, 43: 637-650.
  • 7Cebral JR, Marcelo AC, Rainald L, et al. Recent development in patient-specific image-based modeling of hemodynamics [C]//Mecanica Computacional Vol. XXIII. Bariloche, Argentina, 2004.
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  • 9Cebral JR, Lohner R. Efficient simulation of blood flow past complex endovascular devices using an adaptive embedding technique [ J ]. IEEE transactions in medical imaging, 2005, 24(4): 468-476.
  • 10Moore S, David T, Chase J G, Arnold J, Fink J. 3D models of blood flow in the cerebral vasculature [J]. Journal of Biomechanics, 2006, 39(8): 1454-1463.

共引文献15

同被引文献70

  • 1Glineur D,Hanet C.Competitive flow in coronary bypasssurgery:Is it a problem [J].Curr Opin Cardiol,2012,27(6):620-628.
  • 2Kawamura M,Nakajima H,Kobayashi J,et al.Patencyrate of the internal thoracic artery to the left anterior de-scending artery bypass is reduced by competitive flow fromthe concomitant saphenous vein graft in the left coronaryartery [J].Eur J Cardiothorac Surg,2008,34(4):833-838.
  • 3Villareal RP,Mathur VS.The string phenomenon:An im-portant cause of internal mammary artery graft failure [J].Tex Heart Inst J,2000,27(4):346-349.
  • 4John LC.Biomechanics of coronary artery and bypass graftdisease:Potential new approaches [J].Ann ThoracSurg,2009,87(1):331-338.
  • 5Kleinstreuer C,Hyun S,Buchanan JR Jr,et al.Hemody-namic parameters and early intimal thickening in branchingblood vessels [J].Crit Rev Biomed Eng,2001,29(1):1-64.
  • 6Kabinejadian F,Ghista DN.Compliant model of a coupledsequential coronary arterial bypass graft:Effects of vesselwall elasticity and non-Newtonian rheology on blood flow re-gime and hemodynamic parameters distribution [J].MedEng Phys,2012,34(7):860-872.
  • 7Ding J,Liu J,Wang F,et al. Impact of competitive flow onhemodynamincs in coronary surgery:Numerical study of ITA-LAD model [J].Comput Math Methods Med,2012,DOI:10.1155/2012/356187.
  • 8Berger A,MacCarthy PA,Siebert U,et al.Long-term pa-tency of internal mammary artery bypass grafts:Relation-ship with preoperative severity of the native coronary arterystenosis [J].Circulation,2004,110(11 Suppl 1):1136-1140.
  • 9Hashimoto H,Isshiki T,Ikari Y,et al.Effects of competi-tive blood flow on arterial graft patency and diameter.Medi-um-term postoperative follow-up [J].J Thorac CardiovascSurg,1996,111(2):399-407.
  • 10Nordgaard H,Swillens A,Nordhaug D,et al.Impact ofcompetitive flow on wall shear stress in coronary surgery;Computational fluid dynamics of a LIMA-LAD model [J].Cardiovasc Res,2010,88(3):512-519.

引证文献3

二级引证文献8

中华生物医学工程杂志
2012年 第6期

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