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SirT3调节氧化应激作用 被引量：13

Advancement of SirT3 in oxidative stress
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摘要 依赖于烟酰胺腺嘌呤二核苷酸的去乙酰化酶Sirtuin-3(SirT3)是在进化上高度保守的Sirtuin家族成员之一,能对线粒体内相关的乙酰化蛋白脱乙酰基,通过增加活性氧自由基(ROS)清除酶活性和稳定线粒体功能来抑制线粒体内ROS的蓄积。该文综述了SirT3调节因氧化应激诱发的功能性及器质性损伤的作用和机制,为SirT3在相关病理及生理机制的研究提供有益的参考。 Sirtuin-3（SirT3） is a member of the sirtuin family of nicotinamide adenine dinucleotide（NAD）-dependent deacetylases.SirT3 deacetylates mitochondrial acetylated proteins,then increases the activities of ROS scavenger enzyme and modulates mitochondrial respiratory function,which provide an inhibitory effect on accumulation of reactive oxygen species（ROS）.This review summarizes and introduces the amelioratory effect of SirT3 on oxidative stress-induced functional and organic damage,and provides beneficial references to SirT3 in related pathological and physiological mechanisms for the future researches.
作者 王国恩 翟羽佳 何蓉蓉 栗原博
机构地区 暨南大学中药及天然药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2012年第10期1333-1336,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No 81102485) 广东省自然科学基金资助项目(No S2011040004893)
关键词 SirT3 SIRTUIN 氧化应激 活性氧自由基 去乙酰化作用 乙酰化蛋白 线粒体 SirT3 Sirtuin oxidative stress reactive oxygen species（ROS） deacetylation acetylated protein mitochondria
分类号 R-05 [医药卫生] R329.24 [医药卫生—人体解剖和组织胚胎学]
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参考文献37

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二级参考文献3

共引文献20

同被引文献122

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引证文献13

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中国药理学通报
2012年 第10期

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