钠盐及其调控因素对骨骼影响的研究进展

The research progress of sodium salt and its regulatory factors on bone

高盐的摄入可以引发高血压已有很多研究,随着研究的深入,越来越多的证据表明高盐的摄入还引起骨量丢失,导致骨质疏松和骨折。Na+在生理和病理过程中起着很重要的作用,细胞凋亡、肿瘤生长以及离子转运都与细胞内外的Na+有关,而且Na+与骨骼的关系目前越来越受到关注。该文综述了钠盐及其调控因素:Na+,K+-ATP酶、钠氯共同转运体(NCC)、上皮钠离子通道(ENaC)、肾素-血管紧张素-醛固酮系统(RAAS)对骨骼的影响。

Many studies have confirmed that high salt intake can cause hypertension.With in-depth study,more and more evidences suggest that high salt intake also cause bone loss leading to osteoporosis and fractures.Na＋ plays a very important role in physiology and pathology,and apoptosis,tumor growth and ion transport are related to the intracellular and extracellular sodium.Moreover,the relationship between Na＋ and bone also gets more and more attention.This article reviews the sodium salt and its regulatory factors： Na＋,K＋-ATPase,sodium chlorine co-transporter（NCC）,epithelial sodium channel（ENaC）,and renin-angiotensin-aldosterone system（RAAS） on bone.