慢性肾衰竭患者血清HCY水平与其CysC、CREA的关系

Relationship Between Serum Homocysteine and Cystain C、Creatinine In Chronic Renal Failure Patients

目的:探讨慢性肾衰竭患者血清同型半胱氨酸(HCY)与反映其肾功能指标的胱抑素C(CysC)、肌酐(CREA)之间的关系。方法:用循环酶法在东芝-2100全自动生化分析仪中测定40例慢性肾衰竭患者血清同型半胱氨酸(HCY),同时分别用免疫比浊法测定胱抑素C(CysC),酶法测定肌酐水平;另取100例年龄结构相仿健康体检者作为健康对照组测定其HCY、CysC、CREA水平,并进行统计学上的比较。结果:慢性肾衰竭患者血清HCY水平(22.4±10.2μmol/L)明显高于健康对照组(8.2±5.2μmol/L),两组差异有统计学意义(P<0.05)。结论:慢性肾衰竭患者血清HCY水平明显高于健康对照组,而且随着病程的进展,血清胱抑素C、肌酐水平升高,血清HCY水平也呈上升趋势,血清HCY水平可以作为监测慢性肾衰竭患者发生心血管疾病的一个重要指标。

Objective：To determin the relationship between homocysteine（HCY）and renal function（CysC、CREA）.Methods：The serum HCY levels in patients with chrocic renal failure were determined with enzymatic cycling method,at the same time testing the renal function indicators（CysC、CREA）.Meanwhile 100 healthy subjects with the same age structure were selected as the normal reference group for comparison.Results：Renal function indicators（CysC、CREA）in Chronic Renal Failure patients higher than those of the normal referenc group,especially the HCY level was significantly higher than the normal group（22.4±10.2μmol/L VS 8.2±5.2μmol/L,P0.05）.Conclusions：Hyperhococysteine is commonly seen in Chronic Renal Failure patients and the HCY level will be increased as the renal function indictors（CysC、CREA）increasing.The HCY level can be used to predict their Cardiovascular diseases.