川崎病患儿合并冠状动脉损伤的危险因素分析

Aanalysis of the risk factors of coronary artery lesion with Kawasaki disease in children

目的:探讨川崎病(KD)患儿合并冠状动脉损伤的危险因素。方法:对我院2010年1月～2012年6月收治的符合KD诊断标准的78例KD患儿临床资料、实验室资料及治疗方法进行回顾性分析。结果:KD患儿的性别、发热持续时间、丙种球蛋白使用剂量、丙种球蛋白使用时间、血沉及C反应蛋白等因素与KD合并冠状动脉损伤有关(P<0.05);多因素Logistic回归分析结果显示,KD患儿的性别、丙种球蛋白使用剂量及发热持续时间与KD患儿合并冠状动脉损伤显著相关(P<0.05)。结论:KD患儿的性别、丙种球蛋白使用剂量及发热持续时间为KD合并冠状动脉损伤的独立危险因素,应予足够重视。

Objective：To study the risk factors of coronary artery lesion with Kawasaki disease in children.Method：Retrospectively analysed the clinical data,laboratory data and treatment of 78 children with kawasaki disease（KD）in our hospital from January 2010 to June 2012.Results：Statistical analysis showed that gender,duration of fever,dosage of Gamma globulin using,time of Gamma globulin using,erythrocyte sedimentation rate and C-reaction protein were related to coronary artery lesion（P 0.05）.Multiple logistic regression identified that gender,dosage of Gamma globulin using and duration of fever were independent factors contributing to the development of coronary artery lesion（P0.05）.Conclusion：KD children＇s gender,dosage of Gamma globulin using and duration of fever were the independent risk factors of coronary artery lesion with KD,which should be enough attention.