不同程度慢性乙型肝炎血脂与HBV DNA关系研究

Relationship between blood lipid levels and HBV-DNA in patients with different stages of chronic hepatitis B

目的探讨慢性乙型肝炎患者不同血脂指标的表达水平及其与病情轻重和HBV DNA的关系。方法 收集2011年1月至2012年10月宁波市第二医院142例慢性乙型病毒性肝炎患者以及44名健康献血员血清,检测总胆固醇(TCHO)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、载脂蛋白E(ApoE)、脂蛋白a及HBV DNA,对检测结果进行统计学分析。结果 不同病情及不同HBV DNA载量慢性乙型肝炎患者ApoE水平均显著高于正常对照组(P均<0.05);而其他各血脂指标均低于正常对照组(P均<0.05)。ApoE含量与病情轻重呈正相关,而T-CHO、HDL-C、ApoA1则呈负相关。HDL-C、ApoA1含量与HBV DNA载量呈正相关,而T-CHO、LDL-C、ApoB、ApoE则呈负相关。结论 慢性乙型肝炎患者血脂水平受肝脏合成功能以及HBV本身等多种因素的影响。

Objective To investigate the correlations of dislipidemia with disease stages and HBV-DNA in patients with chronic hepatitis B （CHB）. Methods Serum samples were collected from 142 CHB patients and 44 healthy controls at Ningbo Second Hospital from January 2011 to October 2012, and the levels of TCHO, HDL-C, LDL-C, ApoA1, ApoB, ApoE, lipo and HBV-DNA were detected. The detected data were statistically analyzed. Results Regardless of disease stages and viral loads, the serum ApoE level was higher in CHB patients than that in the healthy controls （ P 〈 0. 05 ） , while the levels of other indicators were lower （ P 〈 0.05 ）. The serum ApoE concentration was correlated positively with disease progres- sion, but the levels of T-CHO, HDL-C, and ApoA1 were correlated negatively with disease stages. The serum ApoA1 concen- tration was correlated positively with HBV-DNA, but the levels of T-CHO, LDL-C, ApoB and ApoE were correlated negative- ly with the viral loads. Conclusion Dislipidemia is affected multiple factors such as liver synthesis function and HBV-DNA in CHB patients.