强化干预高血压、高脂血症对心脑血管疾患发生率的影响

The effects on morbidity of cardio cerebrovascular disorders through intervening hypertension and hyperlipemia

目的 观察强化干预高血压和 /或高脂血症对石化企业老职工心脑血管疾患发生率的影响。方法 1990年茂名石化公司全员大体检中大于 5 0岁在职职工 4146人中 ,检查资料完整者 3916人 ,其中高血压 6 80人 ,高血脂 6 73人 ,高血压合并高脂血症 199人 ,共 15 5 2人 ,随机分为强化干预组 (775人 )和一般治疗对照组 (777人 ) ,比较两组 10年间出现心脑血管终点事件。结果 强化干预组发生心脑血管终点事件比危险因素对照组明显减少 (急性心梗发生率为0 9%比 1 8% ,脑栓塞发生率为 4 2 %比 8 3% ,TIA为 1 4%比 2 4% ,P均 <0 0 1)。石化行业老职工发生危险因素比例较高 (34 6 3% )。结论 对石化行业有心脑血管疾病危险因素者必须积极干预 ,即使是简单的方法和简单的药物治疗 ,亦可显著减少心脑血管终点事件的发生。

Objective To investigate the effects on morbidities of cardio-cerebrovascular disorders in old staff and workers of petrochemical industry enterprise through intervening hypertension and/or hyperlipidemia. Methods To find out 1 552 people, included hypertension 680, hyperlipidemia 673, and hypertension associated hyperlipidemia 199 in 3 916 people with complete data from examined 4 146 staff and workers (age>50 years old) of Maoming Petrol Chemical Company in 1990. They were randomly divided interventional group (775 cases) and control group (777 cases), and cardio cerebrovascular endpoint events were compared between two groups after following up 10 years.Result The incidences of cardio cerebrovascular endpoint events in the interventional group were significantly lower than control group: acute myocardial infarction 0.9% vs 1.8%; cerebral infarction 4.2% vs 8.3%; cerebral hemorrhage 1.4% vs 3.6%; TIA 1.4% vs 2.4% (P<0.01). Conclusion To actively intervene cardio cerebrovascular risk factors for petrochemical occupation, even using simple method or medicine, could significantly decrease cardio cerebrovascular endpoint events.