乳腺癌合并糖尿病患者血清瘦素、癌胚抗原、胰岛素的表达及意义

Expression and significance of serum leptin,carcinoembrionic antigen and insulin in patients with breast cancer who had diabetes mellitus

目的:研究乳腺癌合并糖尿病患者、单纯乳腺癌患者血清瘦素、癌胚抗原、胰岛素的水平变化方法:收集乳腺癌患者(180例),分别为乳腺癌合并糖尿病组(n=98例)、单纯乳腺癌组(n=82例)及正常对照组(n=50例)血清样本,应用酶联免疫吸附法(ELISA法)分别检测血清瘦素、癌胚抗原水平,放射免疫法检测血清空腹胰岛素水平。结果:与正常对照组相比,乳腺癌合并糖尿病组和单纯乳腺癌组的瘦素、癌胚抗原、空腹胰岛素水平显著升高(P<0.01),且乳腺癌合并糖尿痛组的瘦素水平、空腹胰岛素明显高于单纯乳腺癌组(P<0.05):乳腺癌合并糖尿病组与单纯乳腺癌组的癌胚抗原水平比较无统计学意义(P>0.05),瘦素与空腹胰岛素水平呈正相关(r=0.40、P<0.05)。结论:瘦素可能成为乳腺癌合并糖尿病患者的临床诊断的一个重要指标,对预测预后有一定价值,可能为乳腺癌内分泌治疗提供早期的理论依据。

Objective： To investigate the changes in serum leptin, eareinoembryonic antigen and insulin expression in patients with breast eancer who had diabetes mellitus. Methods： A total of 180 patients with breast cancer were assigned to breast cancer group （ n = 82） , concomitant breast cancer and diabetes mellitus group （n =98） and normal control group （n = 50）, respectively. Enzyme-linked immunosorbent assay （ELISA） was employed to detect the expression of leptin and CEA, and radioimmunoassay was adopted for assessment of fasting insulin expression. Results： Compared with normal controls, patients with breast cancer alone or concomitant diabetes were featured by markedly increased serum leptin, carcinoembryonie antigen and fasting insulin （ all P 〈 0.01 ）. Concomitant diabetes resuhed in considerably elevated serum leptin and fasting plasma insulin when compared with breast cancer alone （ both P 〈 0.05 ）. However, between-group comparison did not suggest statistically different levels of serum carcinoembuonie antigen （P 〉 0. 05 ）. The level of leptin correlated positively with fasting insulin （ r = 0. 40, P 〈 0.05 ）. Conclusion ： As a crucial indicator for the diagnosis of patients with breast cancer who had diabetes mellitus, leptin may have the prognostic significance and could offer rationale for early treatment of endocrinological disease in those with breast cancer.