摘要
目的:探讨慢性心力衰竭伴二尖瓣返流(MR)患者血浆N末端脑钠肽前体(NT-proBNP)水平与MR的相关性。方法:心脏超声检测MR后将74例慢性心力衰竭患者并分为MR组(35例)和非MR组(39例),采用酶联免疫吸附法(ELISA)检测血浆NT-proBNP水平,观察两组NT-proBNP水平的差异及其与MR的相关性。结果:MR组和非MR组NT-proBNP水平分别为331.7、135.0 pg/mL,两组比较,差异有统计学意义(P<0.05);LVEF与NT-proBNP水平呈负相关(P<0.05),体质量及MR与NT-proBNP水平与呈正相关(P<0.05)。MR与NT-proBNP偏相关系数为0.672(P<0.05);心功能分级与NT-proBNP偏相关系数为0.737(P<0.05);体质量与NT-proBNP偏相关系数为0.638(P<0.05)。结论:MR是影响老年慢性心力衰竭患者NT-proBNP水平的独立因素。
Objective： To investigate the correlation between mitral regurgitation （MR） and the level of plasma N-terminal brain natriuretie peptide （NT-proBNP） in patients with chronic heart failure. Methods： Seventy-four consecutive patients with chronic heart failure were selected, and divided into two groups according to cardiac ultrasound ： MR group （ n = 35 ） and non-MR group （ n = 39 ）. The level of plasma NT-proBNP was detected by enzyme-linked immunosorbent assay （ELISA） for all patients on admission and the correlation between the level of NT-proBNP and MR was observed. Results： The median NT-proBNP level of the MR group was 331.7 pg/mL vs 135.0 pg/mL in the non-MR group, with a statistical difference between the both （P 〈 0. 05 ）. The level of NT-proBNP was negatively correlated with LVEF （ P 〈 0.05 ） and positively correlated with body mass index and MR （ both P 〈 0.05 ）. The partial correlation coefficient was 0. 672 for NT-proBNP and LVEF （ P 〈 O. 05 ） , 0. 737 for NT-proBNP and level of cardiac function （ P 〈 0.05 ） , and 0.638 for NT-proBNP and body mass index （P 〈 0.05）. Conclusion ： MR is an independent factor that affects the level of NT-proBNP in elderly patients with chronic heart failure.
出处
《广州医学院学报》
2012年第6期51-53,共3页
Academic Journal of Guangzhou Medical College
