肌钙蛋白Ⅰ和D-二聚体联合检测诊断急性心肌梗死的价值

Value of combining detections of troponin I and D-dimer in diagnosing acute myocardial infarction

目的:探讨心脏标志物肌钙蛋白I(CTnI)和D-二聚体(D-DI)联合检测在急性心肌梗死(AMI)诊断中的作用。方法:回顾性分析2010年1月至2011年9月广东省人民医院收治286例急性心源性胸痛患者临床资料,根据病情及入院24 h内的CTnI水平的不同将患者分为2组:A组(急性心肌梗死且CTnI水平≥0.5μg/L,48例),B组(经临床确诊为心绞痛且CTnI水平<0.5μg/L,238例)。比较两组患者D-DI水平的不同。结果:A、B两组患者的血清D-DI水平分别为(333.1±857.98)、(157.0±12.9)μg/L,两组比较,差异有统计学意义(P<0.05)。结论:CTnI和D-DI联合检测更有利于AMI的诊断和预后判断。

Objective：To determine the role of combined detection of cardiac marker troponin 1 （CTnI） and D-dimer （D-DI） in diagnosing acute myocardial infarction （AMI）. Methods： A retrospective analysis was performed on the clinical data of 286 patients with acute cardiac chest pain who admitted to Guangdong Provincial People＇s Hospital between January 2010 and September 2011. The patients were divided into 2 groups according to the severity of their condition and level of CTnI within 24 h from admission： group A （ diagnosed with AMI and CTnI level≥0.5 μg/L, n = 48） and group B （clinically diagnosed with angina and CTnI level 〈 0.5μg/L, n = 238）. The difference in D-DI level was compared between the two groups. Results： There was a statistically significant difference in serum level of D-DI between group A （ 333.1±857.98 ） μg/L and group B （ 157.0 ± 12.9）μg/L （P 〈 0.05 ）. Conclusion： Combined detection of CTnl and D-dimer provides more clinical benefits in diagnosis and prognosis evaluation of AMI.