质子泵抑制剂与安慰剂对喉咽反流患者喉部体征的疗效比较——Meta分析

Comparison between proton pump inhibitor and placebo in improving laryngeal signs of laryngopharyngeal reflux patients ——a Meta analysis

目的通过Meta分析评价质子泵抑制剂(PPI)在改善喉咽反流(LPR)患者的喉部体征方面是否优于安慰剂。方法收集已发表和未发表的有关比较PPI和安慰剂对LPR治疗的随机对照临床研究,对检索到的原始研究的质量进行评估,对符合条件的所有研究结果进行分析。结果共纳入7篇文献,总样本量417例,其中PPI组233例,安慰剂组184例。标准均数差(SMD)为0.53,95%可信区间为(-0.44,1.50),P=0.28。纳入文献中有4篇提供了PPIvs安慰剂治疗12周的数据,SMD为1.12,95%可信区间(-1.54,3.78),P=0.41。结论尚缺乏证据表明PPI治疗在改善LPR患者的喉部体征方面优于安慰剂。

Objective To compare the roles of proton pump inhibitor（PPI） and placebo in the improvement of laryngeal signs of patients with laryngopharyngeal reflux （LPR）. Methods Published and unpublished articles which compare the therapeutic outcomes of LPR using PPI and placebo in randomized controlled clinical trials were collected. The quality of the searched original studies were assessed and the outcomes which are in line with the requirements were analyzed. Results Seven articles met the inclusion criteria, which contained 417 cases in total. There were 233 cases in the PPI group and 184 cases in the placebo group. The standardized mean differences （SMD） was 0.53 with a 95% confidence interval （-O. 44,1.50）, P = 0.28. The data of PPI vs placebo therapy for 12 weeks were provided in 4 articles. The SMD was 1.12 with a 95% confidence interval （ -1.54, 3.78 ）, P = 0.41. Conclusions There was no significant evidence to prove a superior role of PPI compared to the placebo in improving laryngeal signs of LPR patients.