椎间盘退变模型的研究现状及进展

Research Progress on the Intervertebral Disc Degeneration Model

目的：探讨椎间盘退变模型的研究现状及进展。方法：在Pubmed、中国知网查阅有关椎间盘退变模型研究的文献，进行汇总分析。结果：椎间盘退变模型可以通过体外和体内两种方法构建，前者包括椎间盘细胞模型和椎间盘组织模型，后者包括诱发性椎间盘退变模型和自发性椎间盘退变模型。体外模型适用面较广，但培养要求较高，不能全面模拟体内环境；体内培养干预技术较容易实现，但适用面较窄。结论：人椎间盘退变的影响因素繁多，目前的椎间盘退变模型往往具有一定的局限性，无法全面地模拟出人的椎间盘退变情况。无创、微创构建椎间盘退变模型将是未来的发展趋势。

Objective： To discuss the research and development of intervertebral disc degeneration mod- el. Methods：To look for the related articles of the intervertebral disc degeneration model in the database of PubMed as well as CNKI, summarize and analyze those data. Results： Intervertebral disc degeneration model mainly includes in vitro model and in vivo model, the former includes intervertebral disc cell model and disc tis- sue model, the latter includes induced disc degeneration model and spontaneous disc degeneration model. In vitro model is widely applied, but which requires a high culture technique, and it can not simulate the in vivo environment fully; Intervention techniques can be more easily achieved in vivo culture, but it is narrowly appli- cable. Conclusions ： Human intervertebral disc degeneration is affected by many factors ; the current model of in- tervertebral disc degeneration often has certain limitation, which can not completely simulate human interverte- bral disc degeneration. The intervertebral disc degeneration model, constructed by non -invasive, minimally invasive, will be the development trend in the future.