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髓母细胞瘤中Atoh1与Wnt/β-catenin和Shh通路的关系研究进展 被引量：1

The cross-talk between Wnt and Shh signaling pathways by Atoh1 in Medulloblastoma
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摘要 髓母细胞瘤(medulloblastoma,MB)是儿童最常见的脑肿瘤,Wnt与Shh信号通路与MB的发生密切相关。Wnt通路中的β-catenin能抑制Atoh1,而Atoh1调节Shh通路中的Gli2表达,Atoh1作为一个交汇点介导这两条通路的cross-talk。有关Wnt/β-catenin与Shh通路cross-talk的作用机制研究将有助于阐明髓母细胞瘤的发病机制,有望为髓母细胞瘤的治疗提供一种新的策略。 Medulloblastoma （MB） is the most common childhood brain tumors. Wnt and Shh signal pathways are closely related to the occurrence of MB. Recent studies suggest that beta catenin in Wnt pathway inhibits Atohl, which controls Shh pathway by regulating the expression of Gli2. Atohl is an intersection mediates the cross-talk of the two pathways. Further studies on the cross-talk between Wnt and Shh signaling pathways will clarify the machanism of MB and provide new ideas and approaches for treatment on MB.
作者 李昱 唐俐
机构地区 重庆医科大学病理教研室 重庆医科大学病理生理教研室
出处 《中国神经肿瘤杂志》 2012年第4期267-271,共5页 Chinese Journal of Neuro-Oncology
基金 国家自然科学基金(No.81272571) 重庆市自然科学基金(No.2009BB5064)
关键词 髓母细胞瘤 Atoh1 WNT/Β-CATENIN通路 Shh通路 Medulloblastoma Atohl Wnt/15-catenin pathway Shh pathway
分类号 R739.41 [医药卫生—肿瘤]
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参考文献32

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二级参考文献12

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中国神经肿瘤杂志
2012年 第4期

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