非小细胞肺癌与慢性阻塞性肺病患者血清C反应蛋白水平的变化

Changes of C-reactive protein in patients with non-small-cell lung carcinoma and chronic obstructive pulmonary disease

目的探讨非小细胞肺癌(NSCLC)与慢性阻塞性肺病(COPD)患者的血清C反应蛋白(CRP)水平变化。方法采用速率散射法检测NSCLC组(46例)、NSCLC合并COPD组(30例)、COPD组(60例)和健康体检者对照组(38例)血清CRP水平。结果 NSCLC组和NSCLC合并COPD组血清CRP水平明显高于COPD和对照组[(19.32±2.15)mg/L和(23.09±1.98)mg/Lvs.(8.67±1.31)mg/L和(2.79±0.77)mg/L](P<0.01)。早期NSCLC患者血清CRP水平明显低于晚期患者[(14.52±2.34)mg/L vs.(23.29±1.81)mg/L](P<0.01),但明显高于COPD组及对照组(P<0.01)。血清CRP水平与肺癌病理分型及吸烟无相关性。结论慢性炎症在NSCLC及COPD中扮演重要的角色,在NSCLC中尤为明显。

Objective To investigate the changes of C-reactive protein（CRP） in patients with non-small cell lung carcinoma（NSCLC） and chronic obstructive pulmonary disease（COPD）. MethodsSerum levels of CRP were detected by velocity and scattering method in 46 patients with NSCLC （group N）,30 NSCLC patients with COPD（group NC）, 60 patients with COPD）PD（group C） and 38healthy subjects（group D as the controls）. Results Serum levels of CRP were significantly higher in groups of N and NC than those in groups of C and D[（19.32±2.15）mg/L and （23.09±1.98）mg/Lvs.（8.67±1.31） mg/L and （2.79±0.77）mg/L]（P〈0.01）. The patients with NSCLC in early stage had lower serum CRP than those with advanced NSCLC[（14.52±2.34）mg/L vs.（23.29±1.81）mg/L]（P〈0.01）,which was still higher than that in groups of C and D（P〈0.01）. No association was found between serum CRP and histology and smoking status in the patients withNSCLC. Conclusion Chronic inflammation plays an important role in NSCLC and COPD,especially in the former.