细菌分裂Z环定位的调控方式

Regulation of the Z ring positioning in bacterial cell division-A review

细菌细胞的分裂调控机制一直是人们研究的热点。在细胞中部形成一个隔膜,这一看似简单的过程是一个多因子参与调控的过程。Z环(FtsZ ring)是分裂体的支架,Z环形成的位置不仅是隔膜形成的位置还决定着细胞分裂位点,Z环在不正确的位置形成会导致细胞不均等分裂。目前研究已经发现了细胞分裂的多种调控包括Min系统、类核闭塞、MipZ蛋白,通过不同机制可以有效避免Z环的组装,从而阻止了分裂体在不正确的位置形成。就目前研究的Z环形成的过程以及影响Z环定位的调控机制作一综述。

The regulatory mechanism of bacterial cell division has long been a research focus. Forming a septum at the middle of the cell, the seemingly simple process is involved by multiple regulation factors. Zring （FtsZ ring） is the skeleton of the splitting complex. The locus where Z ring is formed is not only the position the septum formed but also determines the cell division site. Formation of Zring in the incorrect location results in inequality cell division. Several cell division regulation systems have been identified, including the Min system, nucleoid occlusion and the MipZ protein which effectively prevent Zring assembly by different mechanisms, ensuring formation of the fission complex at the correct position. Recent progresses about the formation process of Zring and regulation mechanism affecting the Z-ring positioning are summarized.