MMP13在肺鳞癌和肺腺癌组织中的表达及预后价值

Expression and Prognostic Value of MMP13 in Lung Squamous Carcinoma and Adenocarcinoma

目的探讨MMP13在肺鳞癌和肺腺癌组织中的表达,及其与浸润转移和预后的关系。方法采用免疫组织化学法检测48例肺鳞癌和42例肺腺癌组织中MMP13蛋白的表达。结果 MMP13在肺鳞癌和肺腺癌组织中的阳性表达率分别为68.8%(33/42)和64.3%(27/42)(P=0.654)。MMP13蛋白的表达与肺癌的T分期、淋巴结转移和TNM分期相关(P<0.05),而与性别、年龄、吸烟、组织学类型及分化程度等无关(P>0.05)。Kaplan-Meier单因素生存分析显示,MMP13蛋白的表达(P=0.001)、TNM分期(P<0.001)、淋巴结转移(P<0.001)和T分期(P=0.018)对生存期的影响有统计学意义。Cox多因素分析显示,MMP13蛋白的表达(P=0.017)和淋巴结转移(P=0.001)是肺癌的独立预后危险因素。结论 MMP13在肺癌的浸润和转移过程中有着重要的作用,可能是肺癌的一项重要预后指标。

Objective To explore the expression of MMP13 and its relationship with invasion,metastasis and prognosis of lung squamous carcinoma and adenocarcinoma.Methods The expression of MMP13 was detected by immunohistochemistry in tissues of 48 specimens of lung squamous carcinoma and 42 specimens of lung adenocarcinoma.Results The positive expression rate of MMP13 protein in lung squamous carcinoma and adenocarcinoma were 68.8%（33/42）and 64.3%（27/42）（P=0.654）.The expression rate of MMP13 protein was associated with T stages,lymphatic metastasis and TNM stages（P0.05） of lung cancer,not with sex,age,smoking,histological classification and differentiation and so on（P0.05）.Kaplan-Meier univariate analysis revealed MMP13 protein expression（P=0.001）,TNM stages（P0.001）,lymphatic metastasis（P0.001）and T stages（P=0.018） having statistical significance for survival time.Cox model analysis revealed MMP13 expression（P=0.017） and lymphatic metastasis（P=0.001） as dangerous factors of independent prognosis in lung cancer.Conclusion MMP13 plays an important role in invasion and metastasis of lung cancer,and it may be used as an important prognostic indicator of lung cancer.