抑癌基因runx3与原发性肝癌关系的Meta分析

Meta-analysis on Relationship between runx3 Gene and Hepatocellular Carcinoma

目的探索抑癌基因runx3异常甲基化及表达与原发性肝癌易感性的关系。方法采用Meta分析对国内外2004—2011年关于抑癌基因runx3与原发性肝癌易感性的研究文献进行综合计数分析。结果共收集相关文献14篇,累计原发性肝癌病例841例,对照病例800例。runx3基因在肝癌患者癌组织与癌旁组织中的表达有差异,OR值为0.10(95%CI:0.04～0.23),癌组织中runx3基因甲基化程度与癌旁组织有差异,OR值为21.62(95%CI:8.06～57.98)。结论 runx3基因在肝癌组织表达阳性率明显低于癌旁组织,而runx3基因甲基化明显高于癌旁组织,抑癌基因runx3甲基化可导致肝癌细胞表达异常,肝癌的发生发展与runx3基因表达异常及甲基化相关。runx3表达缺失及异常甲基化检测可作为肝癌患者的一种早期辅助诊断指标,而且可能成为分子治疗的靶点。

Objective To study the relationship between aberrant methylation and expression of runx3 gene and susceptibility of primary hepatocellular carcinoma.Methods Research literature of cancer suppressor gene runx3 and primary hepatocellular carcinoma susceptibility home and abroad.Results A total of 841 cases and 800 controls from 14 studies were included.Expression of runx3 gene was different in hepatocellular carcinoma and its para cancer tissue,OR=0.10（95%CI：0.04-0.23）,so was methylation of runx3 OR=21.62（95%CI：8.06-57.98）.Conclusion The positive expression ratio of runx3 gene in the HCC tissue was significantly lower than those in para-cancer tissue.And methylation of runx3 gene was significantly higher than those in para-cancer tissue.Methylation of cancer suppressor gene runx3 will lead to abnormal expression of hepatoma carcinoma cells.Occurrence and development of hepatoma carcinoma has correlation to abnormal expression and methy lation of runx3.Detection of expression missing and abnormal methylation of runx3 could be the early auxiliary diagnosis means for hepatoma carcinoma patients,which could also become the molecular therapy target.