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治疗多发性硬化的口服药物 被引量：7

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摘要 多发性硬化（multiplesclerosis，MS）是一种以中枢神经系统（CNS）炎性脱髓鞘病变为主要特点的自身免疫性疾病，好发于20-40岁的年轻人。来自美国全国多发性硬化学会的资料显示，目前美国MS患者人数约为40万，全球MS患者人数估计超过250万。临床上常用免疫调节剂治疗MS，主要包括干扰素β（INF—β）、醋酸格拉默（glati—rameracetate，GA）、那他珠单抗等，
作者 冯凯 许贤豪
机构地区 北京顺义区医院神经内科 卫生部北京医院神经内科
出处 《中国神经免疫学和神经病学杂志》 CAS 北大核心 2013年第2期89-91,共3页 Chinese Journal of Neuroimmunology and Neurology
关键词 多发性硬化 治疗 投药 口服
分类号 R744.51 [医药卫生—神经病学与精神病学]
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参考文献14

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同被引文献80

  • 1陈健,房志仲.黄芪注射液的药理作用及临床应用[J].天津医科大学学报,2005,11(1):153-157. 被引量：42
  • 2许贤豪.神经系统炎性脱髓鞘病的研究进展[J].中华神经科杂志,2007,40(2):139-141. 被引量：4
  • 3Chiba K,Adachi K.Discovery of fingolimod,the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis[J].Future Med Chem,2012,4(6):771-781.
  • 4Lugaresi A,di Ioia M,Travaglini D,et al.Risk-benefit considerations in the treatment of relapsing-remitting multiple sclerosis[J].Neuropsychiatr Dis Treat,2013,9:893-914.
  • 5Giovannoni G,Comi G,Cook S,et al.A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis[J].N Engl J Med,2O10,362(5):416-426.
  • 6Wegner C,Stadelmann C,Pfrtner R,et al.Laquinimod in terfereswith migratory capacity of T cells and reduces IL-17 levels,inflam-matory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis[J].J Neuroimmunol,2010,227(1-2):133-143.
  • 7Sheridan C.Third oral MS drug wins FDA nod[J].Nat Biotechnol,2013,31(5):373.
  • 8Linker RA,Lee DH,Ryan S,et al.Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway[J].Brain,2011,134(Pt 3):678-692.
  • 9Scannevin RH,Chollate S,Jung MY,et al.Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor(erythroid-derived 2)-like 2 pathway[J].J Pharmacol Exp Ther,2012,341(1):274-284.
  • 10Lee DH,Gold R,Linker RA.Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases:therapeutic modulation via fumaric acid esters[J].Int J Mol Sci,2012,13(9):11783-11803.

引证文献7

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中国神经免疫学和神经病学杂志
2013年 第2期

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