寻常型天疱疮20例临床分析

Clinical Analysis of 20 Cases Pemphigus Vulgaris

目的探讨寻常型天疱疮(PV)的临床特点以及合理的治疗方案。方法回顾分析我院20例PV的临床资料。结果 20例PV病例男女比1∶1.22,以农民和工人为主,入院时大多数病情(90.0%)较重,2种以上合并症8例(40%),创面细菌培养阳性率20.0%,早期足量、及时使用激素、控制并发症,可联合免疫抑制剂治疗;对重症、用常规大剂量激素、免疫抑制剂难控制、有不利于使用激素的并发症的PV联合大剂量人血丙种球蛋白治疗,获得满意的疗效。结论 PV宜早期足量、及时使用激素,控制并发症,可联合免疫抑制剂治疗,对重症多合并症的PV激素难以控制者可联合大剂量人血丙种球蛋白治疗。

Objective To assess the clinical features of pemphigus vulgaris （PV）. Methods The clinical data of 20 patients with PV were retrospectively analyzed. Results Among all the patients, male and female ratio was 1：1.22. 90. 0% were farmers and workers. 90.0% of patients were very severe. More than two complications was 40.0%. 20.0% bacterial culture were positive. Early use of adequate glucocorticoid and complications treatment, appropriate use of immunosuppressant might receive a good result. Additional high-dose of intravenous gammaglobulin was used in the severe patients who had no response to the high-dose of glucocorticoid and immunosuppressant, or they could not take high-dose of glucocorticoid because of the complications. Conclusion The treatment plan of pemphigus vulgaris should give adequate dose glucocorticoid and control the complications in the treatment of the disease as early as possible. It is useful to give additional high-dose intravenous immunoglobulin theranv among lhe severe nafients who had many eomnlicalinng anti no regnonge In high-dase nf glncncnrlieaitt