摘要
In a recent genome-wide association study,the SLC26A4 gene rs2072064 polymorphism was found to be associated with late-onset Alzheimer's disease in Caucasians.Here,we investigated this association in a large Northern Han Chinese cohort consisting of 599 sporadic late-onset Alzheimer's disease patients and 598 healthy controls matched for sex and age in a Northern Han Chinese population from Qingdao,China.Genotyping by the polymerase chain reaction-ligase detection reaction revealed that there were significant differences in the genotype (P=0.017) and allele (P=0.007) frequencies of the rs2072064 polymorphism between late-onset Alzheimer's disease patients and controls.The A allele of this polymorphism was significantly associated with a reduced risk of late-onset Alzheimer's disease (odds ratio (OR)=0.792,95% confidence interval (CI)=0.670-0.937,P=0.007).When the data were stratified by the apolipoprotein E ε4 status,there was a significant difference only among apolipoprotein E ε4 non-carriers (genotypic P=0.001,allelic P=0.001).Furthermore,the association between rs2072064 and late-onset Alzheimer's disease remained significant by logistic regression analysis after adjustment for age,gender,and the apolipoprotein E ε4 carrier status (dominant model:OR=0.787,95% CI=0.619-1.000,P=0.050;recessive model:OR=0.655,95% CI=0.448-0.959,P=0.030;additive model:OR=0.792,95% CI=0.661-0.950,P=0.012).These findings suggest that SLC26A4 is a susceptibility gene for late-onset Alzheimer's disease in a Northern Han Chinese population from the Qingdao area.
In a recent genome-wide association study, the SLC26A4 gene rs2072064 polymorphism was found to be associated with late-onset Alzheimer＇s disease in Caucasians. Here, we investigated this association in a large Northern Han Chinese cohort consisting of 599 sporadic late-onset Alzheimer＇s disease patients and 598 healthy controls matched for sex and age in a Northern Han Chinese population from Qingdao, China. Genotyping by the polymerase chain reaction-ligase detection reaction revealed that there were significant differences in the genotype （P = 0.017） and allele （P = 0.007） frequencies of the rs2072064 polymorphism between late-onset Alzheimer＇s disease patients and controls. The A allele of this polymorphism was significantly associated with a reduced risk of late-onset Alzheimer＇s disease （odds ratio （OR） = 0.792, 95% confidence interval （CI） = 0.670-0.937, P = 0.007）. When the data were stratified by the apolipoprotein E E4 status, there was a significant difference only among apolipoprotein E E4 non-carriers （genotypic P = 0.001, allelic P = 0.001）. Furthermore, the association between rs2072064 and late-onset Alzheimer＇s disease remained significant by logistic regression analysis after adjustment for age, gender, and the apolipoprotein E E4 carrier status （dominant model： OR = 0.787, 95% CI = 0.619-1.000, P = 0.050; recessive model： OR = 0.655, 95% CI = 0.448-0.959, P= 0.030; additive model： OR = 0.792, 95% CI = 0.661-0.950, P = 0.012）. These findings suggest that SLC26A4 is a susceptibility gene for late-onset Alzheimer＇s disease in a Northern Han Chinese population from the Qingdao area.
