老年急性白血病的临床特点(附45例临床分析)

THE CHINICAL CHARACTERISTIC OF ELDERLY PATIENTS WITH ACUTE LEUKEMIA:ANALYSIS OF 45 CASES

目的 :根据老年急性白血病独特的生物学及临床特征 ,寻求治疗老年急性白血病的有效措施。方法 :回顾性分析 45例老年急性白血病 ,其中 30例在积极支持治疗下 ,按个体差异采取不同的化疗方案。结果 :单药化疗组 :低增生性 8例 ,用小剂量三尖杉酯碱 CR2例 (2 5 % ) ,4例 M3用全反式维甲酸均 CR(10 0 % ) ;联合化疗组 :AL L4例 ,CR3例 (75 % ) ,AML14例 ,CR5例 (35 .7% )。30例中总 CR率 46 .7%。结论 :对老年急性白血病的化学治疗应具个体化 ,并进行综合治疗 ,才可望提高老年急性白血病的疗效。

Objective:According to the distinctive biology and clinical characteristic of elderly patients with acute leukemia,explore the ideal treatment.Methods:The data of 45 elderly patients with acute Leukemia were retrospectively analyzed.30 of them were treated with individualized chemotherapy and vigorous supportive care.Results:The ordinary group:2 out of 8 which hypocellular leukemia patients were treated with low dose Har achieved CR(25%);All of AML M 3 4 patients with RA achieved CR(100%);The combination chemotherapy group:The CR rate was 75% for All (3/4) and the CR rate was 35.7% for AML(5/14).The total CR rate of them was 46.7%.Conclusion:The therapy for elder with acute leukemia should be taken with individualized treatment and vigorous supportive care at the same time to improve the CR.