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c-Jun氨基端激酶对亚急性帕金森病小鼠黑质神经元凋亡的影响 被引量：2

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摘要 目的探讨c-Jun氨基端激酶(JNK)对帕金森病(PD)模型黑质多巴胺(DA)能神经元凋亡的影响。方法采用MPTP制备亚急性PD小鼠模型,通过免疫组织化学和免疫蛋白印迹法,观察各组小鼠黑质区磷酸化p-c-Jun免疫阳性反应和蛋白表达水平的变化;观察给予JNK特异性抑制剂SP600125对上述变化的影响。结果与对照组相比,模型组小鼠黑质神经元p-c-Jun表达水平明显升高,TUNEL阳性细胞数量增加;JNK抑制剂组p-c-Jun表达水平明显下降,TUNEL阳性细胞数量显著减少。结论 JNK可能参与模型小鼠黑质DA能神经元凋亡过程;JNK抑制剂SP600125可在一定程度上阻抑黑质区JNK信号通路,减轻MPTP诱导的PD小鼠黑质DA能神经元凋亡。
作者 刘江 李冉 李磊 杨国海 张宇新 张作凤
机构地区 河北联合大学解剖学教研室 承德医学院附属医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第6期1328-1330,共3页 Chinese Journal of Gerontology
基金 河北省自然科学基金(No.H2012401071) 河北省卫生厅医学科学研究重点(No.20110163 20120141 20120145)
关键词 帕金森病 C-JUN氨基端激酶 多巴胺 凋亡
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献8

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二级参考文献9

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共引文献3

同被引文献42

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中国老年学杂志
2013年 第6期

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