血管抑素联合丝裂霉素C防止原发性翼状胬肉术后复发的临床疗效观察

The clinical curative effect of primary pterygium's postoperative recurrence by Angiostatin combined with Mitomycin C

目的观察血管抑素(Angiostatin AS)联合丝裂霉素C(Mitomycin MMC)防止原发性翼状胬肉术后复发的临床疗效。方法对365例(369眼)原发性翼状胬肉随机分成3组,分别采用A组行逆行性翼状胬肉切除术联合丝裂霉素(121眼),B组行逆行性翼状胬肉切除术联合血管抑素(122眼),C组行逆行性翼状胬肉切除术联合丝裂霉素及血管抑素(126眼)等方法治疗,随访12～18个月,比较其复发率。结果 3组间差异具有显著性意义(P<0.05),C组复发率(0.8%,1/126)最低,其次是B组(5.7%,7/122),最后是A组(7.4%,9/121)。结论逆行性翼状胬肉手术联合丝裂霉素C及血管抑制素治疗原发性翼状胬肉,其疗效显著,复发率低,值得推广。

Objective To study the clinical curative effect of primary pterygium＇s postoperative recurrence by Angiostatin combined with Mitomycin C. Methods 365 cases （369 eyes） with primary pterygium were divided into three random groups ： A group （121 eyes） was treated with retrograde resection combined with M MC; B group （122 eyes） was treated with retrograde resection combined with AS and C group （126 eyes） was treated with retrograde resection combined with AS and MMC. Follow-up of 12- 18 months was carried out, the recurrence rate was then compared. Results The difference among the 3 groups was significant （P〈0.05）. Group C recurrence rate （0.8%, 1/126）was minimum, the next was group B （5.7%, 7/122）, and the last was group A （7.4%, 9/121）. Conclusions The retrograde resection combined with AS and MMC is a distinct effective remedy in treatment of primary pterygium. It can achieve good result reduced the recurrence rate and is, therefore, worth spreading.