nm23蛋白与C-erbB-2蛋白在乳腺癌中的表达及临床意义

The expression and clinical significance of nm23 andC-erbB-2 gene protein in breast cancer

目的 :探讨乳腺癌中抑制转移基因nm23的表达及其与C erbB 2、ER、PR以及肿瘤组织学分级、淋巴结转移等临床病理特性的相互关系。方法 :应用免疫组化SP法检测70例乳腺癌中nm23蛋白、C erbB 2蛋白、ER、PR的表达。结果 :乳腺癌中nm23蛋白阳性率为62.86 % ,nm23蛋白的表达与组织学分级、细胞核分级、淋巴结转移以及临床分期均有相关性(P<0.01) ,但与C erbB 2蛋白、ER、PR表达情况无明显相关性。有淋巴结转移组nm23蛋白阳性率为39.47% ,C erbB 2蛋白阳性率为63.16%(P<0.05) ,而nm23蛋白阴性、同时C erbB 2蛋白阳性组的淋巴结转移率为93.33%。结论 :乳腺癌组织中nm23蛋白、C erbB 2蛋白表达情况能提示肿瘤的转移和预后。

Objective:To investigate the expression of metastasis inhibitting gene nm23 in breast cancer and its correlation with C-erbB-2,ER,PR status and tumor histopathological grade and lymph node metastasis.Methods:Immunohistochemistry SP method was used to detect the expression of nm23 protein,c-erbB-2 protein,ER and PR in 70 cases of breast cancer.Results:The positive rate of nm23 protein in breast cancer was 62.86%.The nm23 protein expression inversely correlated with histologic grade,more mitotic figures,lymph node metastasis and clinical stages(P<0.01),but not significantly correlated with expression of C-erbB-2 protein,ER and PR.The positive percentage of lymph node involvement,in the nm23 protein positive was 39.47%,in the C-erbB-2 protein positive was 63.16%(P<0.05),and in the combined nm23-negative and c-erbB-2-positive was 93.33%.Conclusion:It is suggested that nm23 protein and c-erbB-2 protein expression in breast cancer could imply tumor metastasis and prognosis.