胃肠道恶性肿瘤患者治疗前后血清CEA水平的动态分析

Dynamic analysis of the CEA level of patients with gastrointestinal cancer

目的 :探讨治疗前后不同时期胃肠道恶性肿瘤患者血清CEA水平的变化规律及临床意义。方法 :采用CEA单克隆抗体酶联免疫检测试剂盒 ,检测患者血清CEA水平 ,用统计学方法对检测结果进行比较分析。结果 :胃肠道恶性肿瘤患者手术前CEA水平显著高于健康人(P<0.005) ,手术后CEA普遍降低至较低水平。当患者再进行化疗时 ,化疗结束后60天内81.8%(18/22)的患者血清CEA有升高现象 ;61天～180天再次复查时 ,其中13例患者CEA水平又降至化疗前的水平。结论 :手术治疗可降低胃肠道恶性肿瘤患者的血清CEA水平 ;化学药物治疗可使患者出现短暂的(60天内)、可恢复的血清CEA升高过程 ,在此期间内CEA值尚不能作为肿瘤复发或转移的指征。动态分析患者CEA水平对肿瘤诊断和疗效评价有重要意义 ,化疗后患者CEA水平升高的机制待进一步研究。

Objective:To explore the CEA level before and after treatment to assess its clinical significance in gastrointestinal cancer patients.Methods:The serum CEA were detected by CEA ELISA Kits.The results were analysed by statistics.Results:The serum CEA level of gastrointestinal cancer patients was higher than normal controls (P<0.005) and it decreased generally after operation.It would increase for a period (about two months) in 81.8% patients after chemotherapy,then it would decrease to the level before chemotherapy.Conclusion:The serum CEA level could decrease after operation and it would have a returnable increasing period after chemotherapy.During this period the CEA level couldn't be taken as a sign of recurrence and metastases.