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哺乳动物神经发育中的Par极性复合体 被引量：1

Par polarity complex in mammalian neurogenesis
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摘要 哺乳动物的神经发育过程极其复杂,其形态结构和机能变化受到严格的调控。细胞极性是哺乳动物神经发生中最基本的特征之一,在其调控因素中,Par极性复合体是研究最多的蛋白质。神经发育过程中Par蛋白的分布与量呈现动态变化,影响细胞连接建立、细胞极性形成、神经突触发生及神经元迁移,也影响到神经前体细胞的命运。文章主要从胚胎新皮层神经前体细胞及体外培养神经元角度,总结了近年在Par极性蛋白的细胞内分布、机能及作用机制方面的研究进展。 Mammalian neurogenesis is a highly complicated process with programmed morphology and function evolu- tion. Polarity, a basic characteristic in neurogenesis, is controlled by regulating proteins such as the partition defective （Par） proteins. Par polarity complex is the most investigated Par protein among these polarity proteins. There are developmental dynamic changes during neurogenesis for the protein distribution and content, which are related to the junction establish- ment, polarity formation, synaptogenesis, and neuronal migration. Moreover, Par complex is considered to affect the devel- opmental fate of neural precursors. This study summarizes the advances of the protein cellular location, function, and mechanism in embryal neocortex and cultured neuron.
作者 陈慧灵 陈晓萍
机构地区 浙江工业大学生物与环境学院
出处 《遗传》 CAS CSCD 北大核心 2013年第3期281-286,共6页 Hereditas（Beijing)
基金 国家自然科学基金项目(编号:81241097)资助
关键词 Par复合体 神经发生 细胞极性 Par complex neurogenesis cell polarity
分类号 Q42 [生物学—神经生物学]
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  • 1Benedito, R., Roca, C., Sorensen, I., Adams, S., Gossler, A., Fruttiger, M., and Adams, R.H. (2009). The notch ligands DlI4 and Jaggedl have opposing effects on angiogenesis. Cell 137: 1124-1135.
  • 2Bray, S.J. (2006). Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 7: 678-589.
  • 3Campochiaro, P.A. (2000). Retinal and choroidal neovascularization. J. Cell Physiol. 184: 301-310.
  • 4Carmeliet, P. (2000). Mechanisms of angiogenesis and arteriogenesis. Nat. Med. 6: 389-395.
  • 5Chiba, S. (2006). Notch signaling in stem cell systems. Stem Cells 24: 2437-2447.
  • 6Chow, R.L., and Lang, R.A. (2001). Early eye development in vertebrates. Annu. Rev. Cell Dev. Biol. 17: 255-296.
  • 7Delaney, C., Heimfeld, S., Brashem-Stein, C., Voorhies, H., Manger, R.L., and Bernstein, I.D. (2010). Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat. Med. 16: 232-236.
  • 8Dorsky, R.I., Rapaport, D.H., and Harris, W.A. (1995). Xotch inhibits cell differentiation in the Xenopus retina. Neuron 14: 487-496.
  • 9Dou, G.R., Wang, Y.C., Hu, X.B., Hou, L.H., Wang, C.M., Xu, J.F., Wang, Y.S., Liang, Y.M., Yao, L.B., Yang, A.G., and Han, H. (2008) RBP-J, the transcription factor downstream of Notch receptors, is essential for the maintenance of vascular homeostasis in adult mice. FASEB J. 22: 1606-1617.
  • 10Fischer, A., Schumacher, N., Maier, M., Sendtner, M., and Gessler, M. (2004). The Notch target genes Heyl and Hey2 are required for embryonic vascular development. Genes Dev. 18:901-911.

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  • 1桂兰润,王振福.reelin相关基因研究进展[J].国外医学（遗传学分册）,2005,28(6):325-328. 被引量：9
  • 2Rice DS, Curran T. Role of the reelin signaling pathway in central nervous system development I J]. Annu Rev Neurosci, 2001, 24 (1) :1005-1039.
  • 3Zhao S, Frotscher M. Go or stop? Divergent roles of Reelin in radial neuronal migration[J]. Neuroscientist, 2010, 16(4): 421-434.
  • 4Hashimoto-Torii K, Torii M, Sarkisian MR, et al. Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex[J]. Neuron, 2008, 60(2):273-284.
  • 5Hawthorne AL. Repurposing Reelin: the new role of radial glia, Reelin and Notch in motor neuron migration [ J ]. Exp Neurol, 2014, 256 : 17-20.
  • 6Lakoma J, Garcia-Alonso L, Luque JM. Reclin sets the pace of neocortical neurogenesis [ J ]. Development, 2011, 138 ( 23 ) :5223 - 5234.
  • 7Keilani S, Healey D, Sugaya K. Reelin regulates differentiation of neural stem ceils by activation of notch signaling through Disabled-I tyrosine phosphorylation [ J l. Can J Physiol Pharmacol, 2012, 90 (3) :361-369.
  • 8Kipp M, Gingele S, Pott F, et al. BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions[J]. Brain Behav Immun, 2011, 25(8) :1554-1568.
  • 9Bush G, diSibio G, Miyamoto A, et al. Ligand-induced signaling in the absence of furin processing of Notchl [ J ]. Dev Biol, 2001 , 229(2) : 494-502.
  • 10Wodarz A. Establishing cell polarity in development[ J]. Nat Cell Biol, 2002, 4(2) : E39-E44.

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