新生儿血流感染的病原菌分布及耐药性分析

The distributions and drug resistance analysis of pathogenic bacteria in neonatal bloodstream infection

目的:了解新生儿血流感染的病原菌分布特点及耐药情况,为临床合理使用抗生素提供可靠依据。方法:对2010年1月至2011年12月两年间郑州市儿童医院新生儿病房血培养阳性菌株进行鉴定和分析。结果:812例血培养标本中检出病原菌124株,总阳性率为15.3%,其中革兰氏阳性菌株79株,分离率为63.7%,以凝固酶阴性的葡萄球菌为主;革兰氏阴性菌33株,占28.8%,以肺炎克雷伯菌和大肠埃希菌居多;真菌12株,占9.7%,其中以白色念珠菌多见。结论:新生儿血流感染的病原菌以革兰氏阳性球菌为主,尤其以凝固酶阴性的葡萄球菌多见;革兰氏阴性菌及真菌引起的新生儿血流感染也有上升的趋势。

Objective： To investigate the pathogenic bacterias distribution characteristics and drug resistance of the neonatal bloodstream infection to provide reliable basis for clinical use of antibiotics. Methods： The positive strains of blood culture from neonatal wards were identified and analyzed from January 2010 to December 2011. Results： 124 positive strains were detected from 812 cases of blood culture specimens and the positive rate was 15.3%. 79 cases were gram positive strains with separation rate of 63.7% , and the majority of gram positive strains were coagulase negative staphylococcus. 33 cases were gram negative strains with separation rate of 28.8% , and the klebsiella pneumoniae and escherichia coli were the top two classes of gram negative strains. 12 cases were fungi with separation rate of 9.7% , and the majority of fungi were candida albicans. Conclusion： The majority of neonatal bloodstream infection pathogens were gram positive coccus, and the most of which were coagulase negative staphylococcus. Gram negative bacteria and fungi causes of neonatal blood infection were on the uptrend.