摘要
产生促红细胞生成素的肝细胞（erythropoietin-producinghepatocyte，Eph）受体是众多的细胞表面型酪氨酸蛋白激体酶受体中的一种，是酪氨酸蛋白激酶受体家族中的最大成员。其配体主要表达于细胞表面，被命名为ephrin。Eph受体及其配体ephrin统称为Eph家族蛋白。Eph受体属跨膜蛋白，存在胞外配体结合区、跨膜区和胞内区。Eph胞内近细胞膜区域相对保守，包含1个具有酪氨酸残基的高度保守的近膜区结构域，紧接1个具酪氨酸激酶活性的结构域、SAM（sterilealphamotif）结构域和C端的PDZ结合序列。
Erythropoietin-producing hepatocyte （Eph） receptor, a membrane-bound protein tyrosine kinase re- ceptor, plays the function of bidirectional signal transduction by binding to the membrane-tethered ephrin ligands on the neighboring cells. New findings reveal that Eph-ephrin bidirectional transducfion of signals plays roles in embryonic deve- lopment and the physiological metabolism of adult organs, and its dysfunction is involved in a variety of pathological proces- ses, such as cell adhesion and separation, angiogenesis, nerve growth and remodeling, bone remodeling, tumorigenesis and development, immune and metabolic diseases. Therefore, in-depth study of Eph-ephrin is of great significance for under- standing the pathophysiological mechanisms and treatment of diseases. This review discusses the progress in Eph-ephrin bi- directional signal transduction system.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2013年第3期560-564,570,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金青年基金资助项目(No.81000814)
