心通口服液降低动脉粥样硬化和高脂血症药效学研究

The Pharmacological Studies of Xintong Oral Liquid on the Treatment of Atheroscleorsis and Hyperlipemia

心通口服液具有益气养阴、活血化瘀、软坚化痰之功能 ,多年用于临床治疗冠心病心绞痛 ,收到了良好的效果。动物试验表明 :心通口服液高剂量组、维生素 E组、脉安冲剂组 ,均能使高脂大鼠的 CH,TG值降低 ( P<0 .0 1) ,心通口服液高剂量组和维生素 E组还能使 HDL -C值升高 ( P<0 .0 1)。心通口服液高剂量组与维生素 E组能明显降低鹌鹑高血脂模型的 CH和 TG( P<0 .0 1)使 H DC-C值升高 ,并可降低动脉粥样硬化斑块的发生率。

In the terms of traditional Chinese medicine, Xintong oral liquid can supplement the vital energy and nurish yin, soft the hard lumps and dissipate phlegm and promote blood circulation to disperse blood stasis. It has been being a well effective drug for the treatment of coronary heart disease and angina pectoris in clinic for many years. This paper reports the animal test results of Xintong oral liquid on treating atheroscleorsis and hyperlipemia in which showed that high dosage of Xintong oral liquid, as well as vitamin E and Maian granules, could decrease the CH and TG values of hyperlipemia rats (P<0.01). And similar to vitamin E, it could increase their HDL C values (P< 0.01 ). Also same as vitamin E, high dosage of Xintong oral liquid could significantly decrease the CH and TG (P<0.01) and increase the HDL C of hyperlipemia quails and could decrease their incidence rates of atheroscleorsis emplaques.