人参根和茎叶皂甙对大鼠学习记忆障碍改善作用研究

Studies on Effect of Crude Saponin Extracted from Panax ginseng Root or Stem and Leaf on Improving the Learn and Memory Barrier of Rats

采用八肢放射迷路研究人参根及茎叶皂甙对由东莨菪碱所致的大鼠学习记忆损伤的影响。东莨菪碱 ( 0 .3 m g/kg,i.p.)能显著地降低大鼠在放射迷路中最初正确选择数。实验证明人参根皂甙 ( 2 5～ 5 0 m g/ kg,p.o.)和人参茎叶皂甙 ( 12 .5～ 2 5 mg/ kg,p.o.)均能显著地降低由东莨菪碱所致总错误选择。结果表明 ,人参根及茎叶皂甙对东莨菪碱所致大鼠的空间学习记忆损伤有很好的改善作用。

Effects of saponin fraction extracted from Panax ginseng root (Gin R) or stem and leaf (Gin L,S) on scopolamine induced spatial memory disruption were examined using the 8 arm radial maze task in rats. Scopolamine (0.3 mg/kg, i.p.) significantly decreased the percentage of correct responses in the 8 arm radial maze task. Not only the crude saponin extracted from the PG root (12.5～50 mg/kg, p.o.) but also the saponin from PG stem andleaf (12.5～50 mg/kg, p.o.), improved the disruption effect of scopolamine in the radial maze task. These results suggest that the crude saponin fraction of PG stem and leaf, as well as that of PG root, possess beneficial effects on spatial memory deficit in rats.