GnRH依赖型性早熟遗传调控系统研究进展

Research Progress of the Genetic Regulation System in GnRH-dependent Precocious Puberty

性早熟在人类上表现为病理状态,而在家禽生产上则是一个具有重要经济价值的性状。人类性早熟调控机理的研究较为透彻,尤其是近年来全基因关联分析方法的应用,使得研究者对于性成熟启动相关新基因发掘及其调控网络的认识更加深入。论文综述了人类Gn-RH依赖型性早熟(GDPP)的5个基因调控系统,包括kisspeptin系统、γ-GABA系统、NPY和leptin系统、LIN28B系统和NKB系统的研究进展,为禽类早熟性状研究提供依据。

Precocious puberty performs as pathological condition in humans, but it is an important trait in animal production. The research of human precocious puberty regulation mechanism is more thorough, especially in recent years the genome-wide association study method contributes to find more new genes and deeply understand the genetic networks. This paper summarized the progress of genetic systems in hu- man GnRH-dependent precocious puberty, including kisspeptin system, γ-GABA system, NPY and leptin system, LIN28B system and NKB system. These could supply a basis for the relevant study in animals.