骨关节炎患者血浆IL-18、IL-21水平变化及意义

The level changes of IL-18 and IL-21 in patients with osteoarthritis and their significance

目的探讨骨关节炎(OA)患者血浆中IL-18、IL-21的表达及其临床意义。方法采用酶联免疫吸附试验(ELISA)检测OA患者组(35例)、类风湿关节炎(RA)患者组(48例)和股骨头骨折患者组(23例)血浆中IL-18和IL-21水平。对各组患者的年龄、体质量指数(BMI)、白细胞计数(WBC)、红细胞沉降率(ESR)进行测定。结果 RA组WBC较OA和骨折组低(P<0.05);RA组ESR较OA和骨折组高(P<0.05);IL-18在RA组高于OA组,OA组高于骨折组,且差异均具有统计学意义(P<0.05);IL-21在RA组高于OA组和骨折组(P<0.05)。IL-21与ESR变化呈正相关(r=0.35,P<0.05),IL-21与IL-18变化呈正相关(r=0.34,P<0.05)。结论促炎细胞因子IL-18和IL-21在OA中表达增加,可能参与OA的发生和发展,可望成为治疗OA新途径。

Objective To investigate the clinical value of IL-18 and IL-21 in patients with Osteoarthritis（OA）. Methods The plasma samples were collected from 35 patients with OA,48 patients with rheumatoid arthritis（RA） and 23 patients with femoral head fracture（control group） respectively. ELISA was used to detect IL-18 and IL-21. The age,BMI,WBC and ESR of objects was recorded. The statistical software SPSS13.0 was used to analyse the results. Results The level of WBC in RA group was lower than the OA group and fracture group（P〈0.05）. The level of ESR in RA group was higher than the OA group and the fracture group（P^0.05）. The level of IL-18 in OA group was higher than the fracture group,but lower than the RA group（P〈0.05）. The level of IL-21 in RA group is higher than OA group and the fracture group（P〈0.05）. There was positive correlation between IL-21 levels and ESR（r=0.35 ,P〈0.05）. Positive correlation was also found between IL-21 and IL-18（r=0.34,P〈0.05）. Conclusion IL-18 and IL-21 elevated in the patients with OA,which may play the role in the pathogenesis of OA,and to block the IL-18 and IL- 21 may be a potential therapeutic option for treatment of OA.