幽门螺杆菌与急性冠状动脉综合征的相关性研究

The study of the relationship between heliconbacter pylori and acute coronary syndrome

目的探讨幽门螺杆菌感染与急性冠状动脉综合征(ACS)的相关性以及清除HP治疗在ACS治疗中的必要性。方法选取该院2008～2011年住院及门诊的102例ACS患者,并随机抽取128例无ACS的患者作为对照组,检测实验组和对照组患者粪便中的幽门螺杆菌粪便抗原。血清C反应蛋白(CRP)、TG、同型半胱氨酸(HCY)、溶血磷脂酸(LPA)浓度由全自动生化分析仪测得,血浆PLT浓度由HMX全自动五分类血球分析仪测得,FBG由全自动血凝仪ACL7000测得。结果冠心病组粪便幽门螺杆菌粪便抗原阳性率明显高于非冠心病组,冠心病组CRP、PLT、FBG、TG、HCY、LPA浓度均高于非冠心病组(P<0.05)。结论 HP感染与ACS有一定的相关性,对于HP阳性的ACS患者联合给予抗血小板、抗凝、降脂等药物治疗和清除HP是行之有效的方法。

Objective To discusses the correlation between the helicobacter pylori infection and acute coronary syndrome （ACS） and the necessity of clearing HP in acute coronary syndrome （ACS） treatment. Methods Choosing 102 Hospital or outpatients who have acute coronary syndrome （ACS） in our hospital from 2008-2011, and 128 patients who have no acute coronary syndrome （ACS） as comparison,testing the helicobaeter pylori stool antigen from excrement of the experimental group and the comparison group patients, the concentration of Serum CRP,TG, HCY, LPA are measured by automatic biochemical analyzer, the concentration of Plasma Pit are measured by automatic biochemical HMX analyzer, the concentration of Plasma Fbg are measured by automatic AclT000 biochemical analyzer. Results The HP seropositivity rate in the group of ACS was higher than that in the group of conrols there wsa no significant diference in seropositivity rates in the different groups of ACS. Conclusion HP infection and acute coro nary syndrome （ACS） have a certain correlation, giving combined ant platelet, anticoagulation,lipid-lowering and other drugs and clearing HP are effective methods for curing acute coronary syndrome （ACS） patients who are HP positive.