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深圳西部2005~2011年献血者血液复检结果分析 被引量:3

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摘要 目的探讨血清胱抑素C(CysC)对狼疮性肾炎(LN)患者早期肾功能损害监测的意义。方法检测100例系统性红斑狼疮患者的24h尿蛋白,根据尿蛋白结果将患者血清分为两组,阳性组和阴性组,对照组为30例健康体检者,三组分别检测CREA,UREA,URIC,CysC,进行组间比较。结果 UREA、URIC、CREA水平在正常体检组与尿蛋白阴性组之间差异无统计学意义,尿蛋白阳性组水平明显高于阴性组和健康体检组;CysC水平在尿蛋白阳性组与阴性组均高于健康体检组,且尿蛋白阳性组CysC水平明显高于阴性组。血清CysC水平异常率明显高于其他的血清标志物,提示其能更早的发现肾功能的改变。结论血清CysC水平能更好的监测狼疮性肾病患者的肾功能,并且能更早发现患者的肾功能改变,是早期诊断狼疮性肾炎比较好的血清标志物。
出处 《国际检验医学杂志》 CAS 2013年第6期750-752,共3页 International Journal of Laboratory Medicine
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  • 1Fairhurst AM,Wandstrat AE,Wakeland EK. Systemic lupus ery- thematosus:muhiple immunological phenotypes in a complex ge- netic disease[J]. Adv Immuno, 2006,92 (1) : 1-69.
  • 2Stephen MK,Edmund JL, Schwartz MM, et al. Factors predictive of outcome in severe lupus nephritis[J]. Lupus Nephritis Collaho- rative Study Group. Am J Kidney Dis,2000,35(5) 904-914.
  • 3E JM. L J ,T M[J]. The benifit of early treatment with immuno suppressive agents in lupus nephritis. J Rheumatol, 1994,21 ( 1 ) 2046-2051.
  • 4刘新平,谭功军,蔡小慧.胱抑素C在系统性红斑狼疮肾损害中的应用[J].实用预防医学,2012,19(2):274-276. 被引量:8
  • 5Laterza OF, Price CP, Scott MC. An improved estimator of glo merular filtration rate[J], elinieal chemistry, 2002,48 (,q): 699 707.
  • 6龙聪,熊军,郭辉,朱丽莎.血清胱抑素C对系统性红斑狼疮患者早期肾损伤的评估作用[J].实用医学杂志,2011,27(21):3966-3967. 被引量:12

二级参考文献28

  • 1Roos J F, Doust J, Tett S E, et al. Diagnostic accuracy of cystatin c compared to serum creatinine for the estimetion of renal dysfunction in adults and children meta-analysis [J]. Clin Biochem, 2007,4 ( 5 ) : 383-391.
  • 2Fairhurst AM, Wandstrat AE, Wakeland EK. Systemic lupus erythe- matosus: multiple immunologic phenotypes in a complex genetic disease [ J ]. Adv Immuno, 2006,192 : 1 - 69.
  • 3Vyse TJ, Kotzin BL. Genetic susceptibility to systemic lupus erythema- tosus[J ]. Ann Rev Immunol, 1998,16 : 261 - 292.
  • 4Tsokos GC, Kammer GM. Molecular aberrations in human systemic lu- pus erythematosus[J ]. Mol Med Today, 2000,6 : 418 - 424.
  • 5Korbet SM, Lewis EJ, Schwartz MM, et al. Factors predictive of out- come in severe lupus nephritis[J ]. Am J Kidney Dis, 2000,35:904 - 914.
  • 6Esdaile JM, Joseph L, Mackenzie T, et al. The benefit of early treat- ment with immunosuppressive agents in lupus nephritis[J ]. J Rheuma- tol, 1994,21 : 2046 - 2051.
  • 7Newman DJ. Cystatin C[J]. Ann Clin Bioehem, 2002,39:89- 104.
  • 8Abrahamson M, Olafsson I, Palsdottir A, et al. Structure and expression of the human eysta,tin C gene[J]. Biochem J, 1990,268:287 - 294.
  • 9Tenstad O, Roald AB, Grubb A. et al. Renal handling of radiolabeUed human cystatin C in the rat[J]. Scand J Clin Lab Invest, 1996,56: 409 - 414.
  • 10Hahn BH. Antibodies to DNA[J]. N Engl J Med, 1998,338:1359 - 1368.

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