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2型糖尿病患者脂肪细胞功能分析 被引量:4

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摘要 目的研究2型糖尿病(T2DM)患者糖耐量试验中脂肪细胞分泌功能。方法通过T2DM组、对照组葡萄糖耐量样本,观察脂肪细胞分泌脂联素、瘦素、抵抗素,胰腺β细胞分泌胰岛素的动态变化,分析T2DM患者脂肪细胞和胰腺β细胞在葡萄糖耐量试验中的分泌功能变化。结果葡萄糖耐量过程中,T2DM患者脂联素、瘦素、抵抗素、胰岛素餐后分泌下降(P<0.05)。结论脂肪细胞分泌缺陷与β细胞分泌缺陷相关,细胞膜转运障碍导致细胞功能障碍,机体多细胞功能障碍与T2DM发病机制密切相关。
出处 《国际检验医学杂志》 CAS 2013年第6期756-758,I0001,共4页 International Journal of Laboratory Medicine
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  • 1Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ[J]. Mol Cell Endoerinol, 2010,316(2), 129 139.
  • 2Defronzo RA, resistance I. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bet nard Lecture 2009[J]. Diabetologia,2010,53(7) : 1270 1287.
  • 3Mohammadi S, Hosseinzadeh Attar MJ, Hosseinnezhad A, et al. Compare the effects of different visfatin concentration on cardio- vascular risk factors,adiponectin and insulin resistance in patients with T2DM[J]. Diabetes Metab Syndr, 2007,5 (2) : 71-75.
  • 4Giirsoy G,Esbah O,Kirnap NG,et al. The relation of obesity with serum resistin levels in smoker and nonsmokers[J]. J Res Med Sci,2012,17(2) 119-122.
  • 5Kuzmicki M, Telejko B, Szamatowicz J, et al. Highresistin and interleukin-6 levels are associated with gestational di abetes mellitus[J]. Gynecol Endocrinol,2009,25(4) :258-263.
  • 6Ouchi N, Parker J L, Lugus J J, et al. Adipokines in inflammation and metabolic disease[J]. Nat Rev Immunol,2011,11(2) :85-97.
  • 7Go MJ ,Min H,I.ee JY,et al. Association of an Anti inflammatory Cytokine Gene IL4 Polymorphism with the Risk of Type 2 Diabe tes Mellitus in Korean Populations[J]. Genomics Inform, 2011,9 (3) 114-120.
  • 8Tura A,Pacini G,Kautzky-Willer A,et al. Basal and dynamic pro- insulin-insulin relationship to assess beta-cell {unction during OG- TT in metabolic disorders[J]. Am J Physiol Endocrinol Metab, 2003,285(1):155 162.
  • 9Dunning BE, Gerich JE. The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications[J]. Endocr Rev, 2007,28(3) : 253-283.
  • 10葛才保.以细胞膜转运理论分析2型糖尿病发病机理[J].实用糖尿病杂志,2011,7(4):11-13. 被引量:15

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