银丹心脑通软胶囊联合地尔硫■治疗冠状动脉痉挛的临床观察

Clinical therapeutic effect of Yindan Xin Nao Tong combined with diltiazem in treating coronary artery spasm

目的观察银丹心脑通软胶囊联合地尔硫卓治疗冠状动脉痉挛的临床疗效。方法将68例患者按完全随机化分组方法分为治疗组36例和对照组32例,两组患者在诊断为冠状动脉痉挛后开始以地尔硫卓、抗血小板及他汀类药物调脂治疗为主的联合治疗。治疗组在对照组基础上加服银丹心脑通软胶囊,每日3次,每次3粒口服,规格0.4 g每粒。3个月后随访,记录患者的胸痛或胸闷发作的频次(次/个月);复查血脂水平;复查腺苷201核素灌注心肌显像负荷试验。结果经过联合治疗3个月后,治疗组心绞痛发作次数及血脂水平比治疗前和对照组都有明显改善,差异有统计学意义(P<0.05);腺苷201核素灌注心肌显像负荷试验结果显示,治疗组显效和总有效率高于对照组,差异有统计学意义[50.00%(18/36)vs.18.75%(6/32),P<0.05;97.22%(35/36)vs.87.50%(28/32),P<0.05]。结论冠状动脉痉挛在地尔硫卓等药物治疗基础上联合使用银丹心脑通软胶囊治疗,有一定疗效,值得临床进一步观察研究。

Objectives To observe the clinical therapeutic effect of Yindan Nao Xin Tong combined with dihiazem in treating coronary artery spasm （CAS）. Methods A total of 68 patients were randomly divided into 2 groups （36 patients in treatment group and 32 in control group）. Patients of both groups were treated with diltiazem, antiplatelet medicine and statins after being diagnosed as CAS. Treatment group was treated with Yindan Xin Nao Tong along with the medicines taken by control group. Yindan Xin Nao Tong was 0.4 g per pill, taken orally 3 pills per dose and 3 doses per day. After being treated for 3 months, a followed up was conducted to both groups to record the frequency of chest pain and distress, as well as rechecking the level of blood lipids and lab data of adenosine 201 nuclide myocardial perfusion imaging. Results After 3 months, the occurrence rates of chest pain and the levels of blood lipids in treatment group were significandy better than before treating and control group （P〈0.05）. Result of adenosine 201 nuclide myocardial perfusion imaging indicated that significant effective rate and total effective rate of treatment group were significantly higher than those of control group [50.00% （18/36） vs. 18.75% （6/32）, P〈0.05; 97.22% （35/36） vs. 87.50% （28/32）, P 〈0.05]. Conclusions Yindan Xin Nao Tong combined with diltiazem in treating CAS is safe, reliable and worthy of further study.