同型半胱氨酸与脑卒中相关性研究

Relationship between levels of homocysteine and stroke

目的:探讨血浆中同型半胱氨酸(Hcy)与脑卒中的相关性。方法:选择2010年11月～2012年10月在我院神经内科住院治疗的48例脑卒中患者(试验组)和同期48例我院健康体检者(对照组)为研究对象,比较两组血糖、血脂和Hcy水平,探讨血浆中Hcy与脑卒中的相关性。结果:脑卒中患者血糖(GLU)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均高于对照组,差异具有统计学意义(P<0.05),脑卒中患者的Hcy与健康人相比明显偏高,差异具有统计学意义(P<0.05),且男性脑卒中患者的Hcy水平高于女性患者(P<0.05)。结论:血浆同型半胱氨酸的水平与脑卒中的发生率有密切的关系,监测同型半胱氨酸水平可为预防、缓解和治疗脑卒中提供依据。

Objective： To investigate the relationship between levels of homocysteine and stroke. Methods： Forty-eight patients with stroke （the observation group） who were treated in our hospital from November 2010 to October 2012 and forty-eight normal health controls （the control group） were selected, and the levels of blood sugar, blood fat and homocysteine were compared in order to investigate the rela- tionship between levels of homocysteine and stroke. Results.. The levels of GLU, TC, TG, LDL-C and homocysteine of patients with stroke in the observation group were significantly higher than that in the control group（P〈0.05）, the levels of homocysteine in the male patients with stroke were significantly higher than that in the female patients with stroke （P〈0. 05）. Conclusions. Homocysteine plays an important role in stroke; it can provide a basis for prevention and mitigation as well as the treatment of stroke.