血浆NT-proBNP与CRP联合检测在OMI患者心力衰竭诊断中的价值

The value of combined detection of plasma NT-proBNP and CRP for the diagnosis of heart failure in patients with old myocardial infarction

目的探讨血浆N-端脑利钠肽前体(NT-proBNP)和C反应蛋白(CRP)联合检测对陈旧性心肌梗死(OMI)患者失代偿性心力衰竭(心衰)的诊断价值。方法收集2011年3月至2012年1月该院的OMI患者397例,依据纽约心脏病学会(NY-HA)分级标准评价患者心功能,NYHAⅡ～Ⅳ级为心衰组,NYHAⅠ级为非心衰组,另选同期健康体检者105例作为对照组,分别测定各组患者血浆NT-proBNP和CRP浓度。结果 OMI患者NT-proBNP和CRP浓度均显著高于健康对照组(P<0.05);心衰组NT-proBNP和CRP均明显高于非心衰组,心衰组血浆NT-proBNP和CRP水平随NYHA分级增加而逐渐显著升高。结论检测血浆NT-proBNP和CRP有助于OMI患者失代偿性心力衰竭的诊断及心力衰竭程度分级。

Objective To investigate diagnosis value of joint detection for plasma N-end brain natriuretic peptide precursor（NT-proBNP）and C-reactive protein（C-reactiveprotein,CRP）for chronic myocardial infarction（OMI）in patients with decompensated heart failure（hf）.Methods From March 2011to January 2012,397patients of OMI in the hospital were enrolled in this study,according to New York heart association（NYHA）classification standard to assess patients cardiac function,NYHAⅡ-Ⅳ level as heart failure group,NYHAⅠlevel as a non heart failure group,Meanwhile 105cases of health examination were enrolled as control group,the plasma NT-proBNP and CRP were detected for each group.Results For OMI patients NT-proBNP and CRP levels were significantly higher than control group（P0.05）;for heart failure group NT-proBNP and CRP were significantly higher than that of non heart failure group;for heart failure group plasma NT-proBNP and CRP level were increased with NYHA classification.Conclusion detection plasma NT-proBNP and CRP helps OMI decompensated heart failure patients with diagnosis and heart failure classification.