不同浓度的磷酸盐缓冲液(pH7.4)对血塞通注射液稳定性的影响

Influence of Xuesaitong Injection stability by Adding different concentrations of phosphate buffer(pH7.4)

目的:探讨不同浓度的磷酸盐缓冲液(pH7.4)对血塞通注射液稳定性的影响。方法:配制不同浓度磷酸盐缓冲液(pH7.4)的血塞通注射液,80℃加热12天,测定加热第0,1,2,3,4,5,6,7,8,9,10,11和12天注射液中R1、Rg1和Rb1的含量。结果:5%的磷酸盐缓冲液(pH7.4)是维持血塞通注射液稳定的最低浓度。结论:加入浓度大于5%的磷酸盐缓冲液(pH7.4)能有效提高血塞通注射液的稳定性。

Objective： The stability of Xuesaitong （XST） injection containing different concentrations of phosphate buffer （pH7.4） has been investigated in this experiment. Methods ： Heating XST injection adding different concentrations of phosphate buff- er （pH7. 4） 80℃ for 12days, HPLC is used for determining the contents of R1, Rgl and Rbl on heated days 0, 2, 3, 4, 6, 8, 10 and 12. Result： It was found that after heated for 12 days at 80℃, XST injection by phosphate buffer （pH7. 4） to a concentration greater than 5% is stable. Conclusions： By adding a concentration greater than 5% of phosphate buffer （pH7.4） can effectively im- prove the stability of XST injection.