慢性支气管炎急性发作患者痰病原学及耐药性分析

Sputum pathogens and drug resistance analysis of patients with acute exacerbations of chronic bronchitis

目的研究慢性支气管炎急性发作患者的病原学资料及耐药情况。方法我院自2010年1月～2010年12月收治623例慢性支气管炎急性发作的患者,常规开展痰液病原学检测,所有实验菌株均以API系统进行细菌鉴定,采用纸片扩散法,按CLSI药敏试验抗菌药物分组原则进行。结果合格痰液标本共分离出菌株448株,其中革兰氏阴性菌占主要,假单胞菌最多,达18.4%。其中,检出产ESBL酶菌株13株,主要由假单胞菌产生;产MRSA酶5株,全部由葡萄球菌产生;多重耐药不动杆菌8株,主要由鲍曼不动杆菌产生。结论慢性支气管炎急性发作患者病原菌中革兰氏阴性菌占主要,且耐药情况较为严重,应引起临床高度重视。

Objective Study on acute exacerbation of chronic bronchitis patients and drug resistance of pathogenic data.Methods Respiratory department of our hospital from 2010 January to 2010 December,623 cases of acute exacerbation of chronic bronchitis treated with routine of sputum pathogenic detection.All experimental strains were API system for bacterial identification,using the disc diffusion method,according to the CLSI drug sensitive test of antibacterial drug grouping principle.Results Qualified sputum samples were isolated from the strain of 448 strains of Gram-negative bacteria,which accounted for the main,Pseudomonas most 18.4%.The detection of ESBL enzyme-producing strains of 13 strains of,mainly produced by a Pseudomonassp;MRSA enzyme-producing strain 5,all produced by staphylococcus;Multiple drug resistance of Acinetobacter strains of 8,mainly produced by Bauman acinetobacter.Conclusion Patients with acute exacerbations of chronic bronchitis pathogens in Gram-negative bacteria accounted for a major.The situation is more serious and resistance,clinicians should pay more attention.