突发性聋与血脂代谢异常的相关性研究

The correlation study of sudden deafness with dyslipidemia

目的通过分析成年突发性聋患者血脂代谢特点,探讨突发性聋的发病机制与血脂代谢异常的关系。方法回顾分析260例突发性聋患者血清中甘油三酯(TG)、总胆固醇(CHOL)、低密度脂蛋白胆固醇(LDL)、高密度脂蛋白胆固醇(HDL)、载脂蛋白A1(Apo-A1)、载脂蛋白B(Apo-B)的含量,并以同期住院治疗的非耳科疾病患者(听力正常)260例血脂水平作为对照进行统计分析。结果突发性聋组患者TG、CHOL、LDL、Apo-B水平均高于听力正常组患者,差异有统计学意义(P<0.05);2组间HDL和Apo-A1水平差异无统计学意义(P>0.05);Logistic多因素分析显示LDL是突发性聋发病的主要危险因素,而Apo-A1是突发性聋发病的保护因素。结论突发性聋患者血脂水平高于听力正常群体,患者LDL与Apo-A1水平与突发性聋的发病率具有相关性。

Objective To analyze the features of adult patients with sudden deafness lipid metabolic characteristics, to investi- gate the relationship between sudden deafness and dyslipidemia. Methods Serum content of triglyceride （TG）, total cholesterol （ CHOL）, low density lipoprotein cholesterol （ LDL）, high density lipoprotein cholesterol （ HDL）, apolipoprotein A1 （ APOA1 ）, apoli- poprotein B （APOB） in 260 cases with sudden deafness patients were retrospectively analyzed, and compared with 260 non -otology disease patients （normal hearing） that received therapy in hospital at the same time. The lipid of two groups carried on the statistical a- nalysis. Results The level of TG, CHOL, LDL and APOB in sudden deafness group was higher than normal hearing patients, there was significantly difference （ P 〈 0.05） ; there was no statistical difference of the level of HDL and APOA1 in the two groups （ P 〉 0.05 ） ; Logistic multiple factors analysis showed that LDL was a major risk factor for the incidence of sudden deafness, while APOA1 was the protective factor. Conclusion Lipid levels in patients with sudden deafness are higher than that in normal hearing group, the level of LDL and APOAI has relationship with the incidence of sudden deafness.