雷公藤片的临床应用及不良反应文献分析

Bibliometric analysis on clinical application and adverse reaction of Tripterygium Wilfordii Tablet

目的分析雷公藤片临床应用及不良反应文献,为其临床合理应用提供参考。方法检索中国生物医学文献数据库、中国知网、维普中文期刊数据库收录的雷公藤片临床应用和不良反应文献,采用循证医学和情报学原理进行文献筛选和分析。结果临床应用文献19篇,涉及病例783例,不良反应案例报道8篇,涉及病例24例;雷公藤片对类风湿关节炎、斑秃、子宫内膜异位等10种疾病的有效率均在81.91%以上,不良反应主要表现为胃肠道不适、闭经、色素沉着等。结论雷公藤片是治疗类风湿关节炎的有效药物,对斑秃、子宫内膜异位、巩膜炎、慢性荨麻疹等疾病有潜在的治疗前景,但其安全性和有效性还有待进一步验证。

Objective To analyze the literatures on clinical application and ADR of Tripterygium Wilfordii Tablet（TW） to provide reference for its rational use in clinic.Methods The literatures for the clinical application and ADR of TW were retrieved in the databases of CBM,CNKI and VIP.The related literatures were screened out and analyzed by evidence-based medicine method and bibliometric statistical method.Results 783 cases were found in 19 clinical literatures and 24 cases were included in 8 ADR literatures.The effective rates of TW to the 10 diseases were all above 81.91%,such as rheumatoid arthritis,alopecia areata and endometriosis.ADR is mainly stomach upset,amenorrhoea,hyperpigmentation,etc.Conclusion TW is proved to have prominent effects on rheumatoid arthritis.It also has the latent treatment prospect on alopecia areata,endometriosis,scleritis,chronic urticaria and the other diseases,but the safety and effect need to be further verified.